电针足三里和阳陵泉穴对家兔胃胆运动及脑肠肽的影响  

Effects of electroacupuncturing at Zuyangming and Zushaoyang Jingxue on stomach and gallbladder kineses and related brain-gut peptide in rabbits

作　　者：常小荣[1] 严洁[1] 刘玉群[1] 张泓[1] 易受乡[1] 林亚平[1] 

机构地区：[1]湖南中医药大学针灸推拿学院,湖南省长沙市410007

出　　处：《世界华人消化杂志》2006年第17期1662-1668,共7页World Chinese Journal of Digestology

基　　金：国家973计划中医理论基础研究专项;No.2005-CB523308~~

摘　　要：目的:研究经脉-脏腑相关理论及经穴对相应脏腑的特异性作用．方法:静脉滴注阿托品造成家兔(n=50)胃和 Oddi括约肌运动抑制状态,观察电针家兔足三里穴及阳陵泉穴对胃电及Oddi括约肌肌电的影响并检测血浆和胃窦平滑肌及Oddi括约肌组织中胃动素(MTL)胆囊收缩素(CCK)的含量．结果:静滴阿托品后家兔胃电和Oddi括约肌肌电慢波高活动相平均振幅(P=0．001和快波平均振幅(P=0．028,P=0．001)明显降低;慢波平均频率变化不明显．电针足三里穴和阳陵泉穴对家兔胃电(P=0．020,P=0．0001及Oddi 括约肌肌电(P=0．021,P=0．001)平均振幅有不同程度的兴奋作用,表明经脉-脏腑之间既有直接相关又有间接相关．电针足三里穴和阳陵泉穴可升高胃窦平滑肌、Oddi括约肌组织及血浆中MTL(P=0．000)、CCK((P=0．001)含量．电针足三里穴对胃窦平滑肌和血浆MTL (P=0．020,P=0．001)及血浆CCK(P=0．001)含量升高最显著,差异有显著性意义．Oddi括约肌MTL及胃窦平滑肌、Oddi括约肌CCK以电针阳陵泉穴明显．提示MTL和CCK是参与针刺调整消化道运动的重要脑肠肽物质．结论:电针足三里和阳陵泉穴可促进胃和 Oddi括约肌运动,其机制之一可能为针刺影响外周MTL、CCK的释放,进而调整消化道运动．这种经穴对相应脏腑的调整作用具有相对特异性．AIM： To investigate the correlation between the meridians and zang-fu as well as the specific effect of the points on their related zang-fu. METHODS： Atropine was intravenously injected in the rabbits to inhibit the myoelectric activities of the stomach and the sphincter of oddi （SO）. After electroacupuncturing at Zusanli and Yanglingquan points, the myoelectric activities of the stomach and SO were observed, and the levels of motilin （MTL） and cholcystokinin （CCK） in the antrum, SO and plasma were measured. RESULTS： After atropine injection, the mean amplitudes for the high activity of myoelectric slow wave and fast wave were significantly decreased （P = 0.028, P = 0.001）. Moreover, the average frequency of myoelectric slow wave was not significantly changed. The mean amplitudes for the myoelectric slow wave and fast wave were enhanced to some extent after electroacupuncturing at Zusanli and Yanglingquan points. The levels of MTL （P = 0.000） and CCK （P = 0.001） in the antrum, SO and plasma were increased markedly after electroacupuncturing at Zusanli and Yanglingquan points. The levels of MTL in the antrum （P = 0.020） and plasma （P - 0.001） and CCK in plasma （P = 0.001） were obviously increased after electroacupuncturing at Zusanli point, whereas the levels of MTL in SO and CCK in the antrum and SO were notably increased after electroacupuncturing at Yanglingquan point. There was a positive effect on the release of MTL and CCK after electroacupuncturing at the points. CONCLUSION： The inhibition for the myoelectric activities of the stomach and SO are improved after electroacupuncturing at Zusanli and Yanglingquan points. The possible mechanism may be that the acupuncture influences the release of MTL and CCK, so as to regulate the activity of the alimentary canal.

关 键 词：电针 足三里 阳陵泉 ODDI括约肌 胃动素 胆囊收缩素 

分 类 号：R245[医药卫生—针灸推拿学]