高血压患者抗α_1肾上腺素受体抗体与心脏重构的临床观察  

Autoantibodies againstα_1 adrenergic receptor related with cardiac remodeling in hypertensive patients by clinical observation

作　　者：李正在[1] 廖玉华[1] 周子华[1] 魏宇淼[1] 王敏[1] 朱锋[1] 陈明[1] 杜雄兵[1] 孙艳香[1] 张海燕[1] 

机构地区：[1]华中科技大学同济医学院心血管病研究所 华中科技大学同济医学院附属协和医院心内科,武汉430022

出　　处：《中华心血管病杂志》2006年第7期602-604,共3页Chinese Journal of Cardiology

基　　金：国家973高技术计划发展基金资助项目(G2000056900)

摘　　要：目的观察抗α1肾上腺素受体抗体(简称α1受体抗体)对高血压患者心室重构的影响。方法采用酶联免疫吸附法(ELISA)对553例高血压患者进行血清抗α1受体抗体检测并记录所有患者的超声心动图检查结果。运用多元logistic回归分析高血压患者左心室扩大的影响因素。结果553例高血压患者血清抗α1受体抗体阳性率为32．3％(179／553)。抗α1受体抗体阳性组中左心房扩大占的比例明显高于阴性组(分别为53．6％,44．3％,P<0．05);阳性组中左心室扩大所占比例也明显高于阴性组(分别为12．8％,6．1％,P<0．01)。多元logistic回归共筛选出4个左心室扩大的危险因素:男性、病程、心率、血清抗α1受体抗体(P均<0．05)。结论抗α1受体抗体与高血压患者左心室扩大有关,该抗体阳性可能对预测高血压患者左心室重构具有重要意义。Objective To investigate the effects of autoantibodies against α-adrenergic receptor on cardiac remodeling in patients with hypertension. Methods Five hundred and fifty three patients with hypertension in our hospital were selected. The autoantibodies against α1 adrenergic receptor in sera of donor were detected by ELISA, and the results of echocardiography were recorded. By multiple logistic regressions, the risk factors were analyzed on left ventricular enlargement of hypertension. Results The percentage of autoantibodies against α1 adrenergic receptor positive was 32. 3% （ 179/553 ）. There were significant difference between the positive group and negative group on the ratio of left atrial enlargement （53. 6% , 44. 3% , respectively;P 〈0. 05） and left ventricular enlargement （ 12. 8%, 6. 1%, respectively; P 〈 0. 01 ）. The result of regression analysis demonstrated that 4 risk factors were related to left ventricular enlargement, including male, course of disease, heart rate （HR） and autoantibodies against α1 adrenergic receptor in the serum （ all P 〈 0. 05 ）. Conclusions The autoantibodies against α1 adrenergic receptor have a relationship with left ventricular enlargement of hypertension. Patients with the activity of autoantibodies against α1 adrenergic might contribute to predict cardiac remodeling.

关 键 词：高血压 受体 肾上腺素能α 自身抗体 心脏复建 

分 类 号：R544.1[医药卫生—心血管疾病]