人胃癌组织中VEGF-C及其受体Flt-4的表达  

The expression of VEGF-C and Flt-4 in human gastric cancer

作　　者：李玉兰[1] 徐晶莹[1] 张雅芳[1] 李益民[1] 吕岩红[1] 杨树才[1] 赵玲辉[1] 

机构地区：[1]哈尔滨医科大学人体解剖学教研室,哈尔滨150086

出　　处：《中国临床解剖学杂志》2006年第4期422-424,共3页Chinese Journal of Clinical Anatomy

基　　金：黑龙江省卫生厅科学技术研究项目(2004-170);黑龙江省科技厅攻关课题(GC03C606-1);黑龙江省教育厅课题(10511071)

摘　　要：目的:观察VEGF-C和Flt-4在胃癌组织及淋巴管的表达,探讨癌细胞淋巴管转移机理。方法:用免疫组化方法检测人胃癌早期和进展期癌细胞和淋巴管VEGF-C和Flt-4的表达情况。结果:在各期胃癌的癌细胞中均见到VEGF-C和Flt-4阳性表达,淋巴管内皮细胞仅见到Flt-4阳性表达;进展期胃癌两种蛋白的表达率和表达强度都高于早期癌。结论:癌细胞VEGF-C和Flt-4的表达与肿瘤进展呈正相关;淋巴管上Flt-4的表达也与胃癌的进展呈正相关。推测VEGF-C可能通过其受体Flt-4诱导胃癌组织淋巴管发生。Objective： To study the expression of VEGF-C and Fit-4 in tissues and lymphoducts of gastric cancer and elucidate the mechanism of lymphatic metastasis of cancer cell. Methods： To examine the expression of VEGF-C and Fit-4 in cancer cells and lymphatics of primary and developing gastric cancers by immunohistochemical staining. Results： Both VEGF-C and Fit-4 expressed at every stage of gastric cancer. Only Fit-4 expression can be observed in endothelial cells of lymphatics. The rate and intension of VEGF-C and Fit-4 proteins expression were higher in developing cancers than in primary cancers. Conclusions：The expression intension of VEGF-C and Fit-4 in cancer cells, as well Fit-4 in lymphatics, has positive correlation with the cancer developing. It suggests that VEGF-C may induce lymphatics generation by its receptor Fit-4.

关 键 词：胃癌 VEGF-C Fit-4 免疫组化 

分 类 号：R332[医药卫生—人体生理学] R735.2[医药卫生—基础医学]