新疆维吾尔族2型糖尿病家系成员体质量指数与糖代谢、血脂、血压的关系  

Relationship of body mass index to glycometabolism, blood lipid and blood pressure in family members of type 2 diabetes in Xinjiang Uigur

作　　者：曾小云[1] 谢自敬[1] 阿不力克木[1] 伊力哈木[1] 

机构地区：[1]新疆医科大学第一附属医院内分泌科,新疆维吾尔自治区乌鲁木齐市830054

出　　处：《中国临床康复》2006年第32期30-31,共2页Chinese Journal of Clinical Rehabilitation

摘　　要：目的:分析新疆维吾尔族2型糖尿病家系成员体质量指数与糖代谢、血压、血脂的关系,借以探讨家系成员体质量指数的适宜切点。方法:抽取新疆和田地区维吾尔族2型糖尿病家系21个,16岁以上家系成员365人,按体质量指数分为6组,比较各组血糖、胰岛素抵抗、血压及血脂的情况。非条件Logistic回归分析不同体质量指数切点作为独立因素与2型糖尿病的相关联系。结果:365例成员纳入结果分析。①随体质量指数水平的升高,服糖后2h血糖、空腹及服糖后2h胰岛素、收缩压和舒张压、总胆固醇、三酰甘油、稳态模式胰岛素抵抗指数均呈上升趋势,各体质量指数组间比较差异有显著性意义(P<0.001)。②体质量指数<23kg/m2的两组,空腹血糖和服糖后2h血糖分别为(5.93±2.97)mmol/L和(7.75±6.02)mmol/L,接近空腹血糖及糖耐量异常标准。③体质量指数≥25kg/m2和体质量指数≥27kg/m2时,分别出现空腹糖耐量受损和糖耐量异常。④非条件Logistic回归分析显示体质量指数≥23kg/m2,糖代谢异常OR=2.05,P=0.0477暴露组归因危险百分比为51.22%。结论:随体质量指数增高,新疆维吾尔族2型糖尿病家系成员的血糖、血脂、血压增高,体质量指数≥23kg/m2后,糖代谢异常的危险性增加。AIM： To investigate the relationship between body mass index （BMI） and glycometabolism, blood pressure, blood lipid in family members of type 2 diabetes of Xijiang Uigur Autonomous Region, so as to probe into the suitable incisor point in family members. METHODS： Twenty-one Uigur family constellations of type 2 diabetes in Xinjiang Tianhe region were selected including 365 relatives who were older than 16 years. Subjects were divided into 6 groups according to the BMI, and the levels of blood glucose, insulin resistance, blood pressure and blood lipid were compared among all groups. Non-condition Logistic regression analysis was adopted to analyze the correlations between type 2 diabetes and different BMI. RESULTS： A total of 365 subjects were involved in the analysis of results.①As the increase of BMI, the levels of blood glucose at two hours after Orally taking glucose, fasting insulin and insulin at 2 hours after orally taking glucose, systolic blood pressure, diastolic blood pressure, total cholesterol, triacylglycerol and homeostasis model assessment insulin resistance （HOMA-IR） were in a ascending trend, and there were significant differences in BMI among groups （P 〈 0.001）.②The fasting blood glucose and that of 2 hours after orally taking glucose in patients with the BMI 〈 23 kg/m^2 were respectively （5.93 ：t=2.97） mmol/L and（7.75±6.02） retool/L, which were close to the abnormal standard of fasting blood glucose and sugar tolerance. ③There were impaired sugar tolerance and abnormal sugar tolerance while the BMI ≥ 25 kg/m^2 and the BMI ≥ 27 kg/m^2.④Non-condition Logistic regression analysis showed that when the BMI ≥23 kg/m^2, the glycometaboilsm was abnormal OR=2.05, P =0.047 7, and the ARP of the exposure group was 51.22%. CONCLUSION： With the increase of BMI, the blood glucose, blood lipid and blood pressure in family members of type 2 diabetes of Xinjiang Uigur are increased, and the danger in abnormal glycometabelism increased after the BMI ≥ 23 kg

关 键 词：糖尿病 非胰岛素依赖型 人体质量指数 病理学 生理学 脂类 

分 类 号：R587.1[医药卫生—内分泌]