绿麦隆复合体系对小鼠睾丸组织的影响  

Effect of chlorotoluron system on the testis of mice

作　　者：穆洪[1] 张平[2] 杨圣婴[3] 徐建[2] 

机构地区：[1]南开大学医学院,天津300071 [2]南开大学环境科学与工程学院,天津300071 [3]南开大学化学院,天津300071

出　　处：《中国临床药理学与治疗学》2006年第6期673-676,共4页Chinese Journal of Clinical Pharmacology and Therapeutics

摘　　要：目的:研究绿麦隆复合体系对小鼠睾丸组织的影响。方法:雄性昆明小鼠经口染毒绿麦隆25 d,取睾丸组织作为标本观察。结果:绿麦隆单体系及复合体系各剂量组对小鼠睾丸均有不同程度的改变。光镜观察所见:生精上皮细胞排列疏松、紊乱;生精细胞脱落,层次减少。电镜观察所见:生精细胞线粒体呈空泡样改变,核膜肿胀、弯曲,支持细胞数目减少,部分细胞紧密连接破坏。结论:小鼠睾丸呈细胞退行性改变趋势,随剂量增加及复合染毒,病变加重。AIM：To study the effect of chlorotoluron system on the tesis of mice. METHODS： Male mice were contaminated with chlorotoluron by oral for 25 days. RESULTS： It indicated that all doses of herbicide had different changes. It was detected that under the light microscope seminaferous epithelium arrayed loosely and disorderedly, spermatogenic cell shed, layers lessened, while under the electron microscope mitochondria in the seminaferous epithelium appeared vacuolated, karyotheca swelled and bent, the amount of sustentacular cell declined, and part of tight junction destroyed. CONCLUSION： The trend of degeneration and more seriously pathological changes appeared with increasing doses.

关 键 词：绿麦隆 小鼠 睾丸 

分 类 号：R965.1[医药卫生—药理学]