蜂王浆类制剂SK初乳素R-1对小鼠免疫功能的影响  

Immunoloregulation effect of SK Royaljelly R-1 in mice

作　　者：谭虎[1] 钱之玉[1] 

机构地区：[1]中国药科大学药理教研室

出　　处：《中国临床药理学与治疗学》2006年第6期684-686,共3页Chinese Journal of Clinical Pharmacology and Therapeutics

摘　　要：目的:研究蜂王浆类制剂SK初乳素R-1对正常小鼠非特异性免疫功能、体液免疫功能、功细胞免疫功能的影响。方法:以SK初乳素R-1连续灌胃给药15 d,测定小鼠增强小鼠炭末廓清能力、小鼠血清溶血素抗体水平、血清IL-2含量、抗体生成细胞数、脾淋巴细胞增殖能力等。结果:SK初乳素R-1各剂量组能增强小鼠炭末廓清率和廓清指数,各剂量组均能明显升高小鼠血清溶血素抗体水平(P<0.01),提高小鼠血清IL-2含量(P<0.01),促进小鼠抗体细胞形成(P<0.01),增强ConA诱导的脾淋巴细胞增殖能力(P<0.01)。结论:蜂王浆类制剂SK初乳素R-1具有增强小鼠免疫功能的作用。AIM： To investigate the effect of SK Royaljelly R-1 （SKR） on the innate immunity, humoral immunity, cell immunity in mice. METHODS： Observe the effect of SKR on immunity function in mice, the phagocytotic rate and phagocytotic index, haemolysin in serum, plaque forming cell, and the proliferation of splenocyte following administration SKR for 15 days. RESULT： SK Royaljelly R-1 improved the formulation of se-rum haemolysin significantly （ P 〈 0.01 ）, increased PFC and Il-2 production significantly （ P 〈 0.01 ）, and stimulated the splenocyte proliferation stimulated by ConA of normal mice （ P 〈 0.01 ）. CONCLUSIION： The results suggeste SKR could potentiate the immunological function of normal mice.

关 键 词：蜂王浆 免疫 溶血素 溶血空斑 IL-2 

分 类 号：R965.1[医药卫生—药理学]