初发2型糖尿病胰岛素治疗剂量的门诊观察  

Dosage of insulin treatment on newly diagnosed type 2 diabetics

作　　者：唐平[1] 杨川[2] 李莉[3] 曾映娟[2] 杜婧[2] 

机构地区：[1]深圳市罗湖区人民医院内分泌科 [2]中山大学附属第二医院内分泌科 [3]中山大学附属第二医院急诊科

出　　处：《中国临床药理学与治疗学》2006年第6期687-690,共4页Chinese Journal of Clinical Pharmacology and Therapeutics

摘　　要：目的:探讨门诊首次诊断糖尿病人应用胰岛素进行治疗的剂量。方法:32名门急诊糖尿病人,分别应用双相门冬氨酸胰岛素30(商品名:诺和锐30)(20例)及诺和灵30R(12例)进行血糖控制,观察血糖的变化,调整胰岛素的用量。结果:初次诊断时空腹血糖(FPG)、餐后2 h血糖(PPG)两组间无统计学差异。两种胰岛素治疗1周后两组间空腹血糖(FPG)无统计学差异,而诺和锐30组餐后2 h血糖(PPG)低于诺和灵30R组(P<0.05);达到血糖控制标准时,诺和锐30组达标时间较诺和灵30R组短(P<0.05);血糖控制达标后继续观察1个月,诺和锐30组胰岛素维持剂量低于诺和灵30R组(P<0.05)。结论:对于门诊初次发现糖尿病的患者,应用诺和锐30的效果可能较诺和灵30R更加显著。AIM： To study the insulin dosage on newly diagnosed type 2 diabetics. METHODS： Thirty-two newly diagnosed type 2 diabetics were treated by biphasic insulin aspart 30 （BIAsp30） （ group Asp30, n = 20） and Novolin 30R （group Novolin 30, n = 12）respectively. The levels of plasma glucose and insulin dosage were evaluated. RESULTS： There were no significant change in fasting plasma glucose and postprandial glucose before treatment in the two groups. After one week＇s treatment there was no significant change in fasting plasma glucose in both groups, while the postprandial plasma glucose in Asp30 was significantly lower than that in Novolin 30 （P 〈 0.05）. When the controlling of plasma glucose meets the standard , the time costed in group Asp30 was signifi- cant lower compared with group Novolin 30. The maintenance dosages before breakfast and before dinner were also significantly lower in group Asp30 than that in group Novolin 30 （ P 〈 0.05 ） in further observation. CONCLUSION： It is better to use BIAsp30 than to use Novolin 30R on newly diagnosed type 2 diabetics.

关 键 词：2型糖尿病 胰岛素类似物 血糖 

分 类 号：R969.3[医药卫生—药理学] R587.1[医药卫生—药学]