老年2型糖尿病胰岛素抵抗和胰岛β细胞功能的初步探讨  

Preliminary study on insulin resistance and the function of islet βcells in elderly patients with type 2 diabetes mellitus

作　　者：王静[1] 刘永煌[1] 熊黎[1] 

机构地区：[1]贵州省人民医院干医科,贵阳550002

出　　处：《贵州医药》2006年第7期597-599,共3页Guizhou Medical Journal

摘　　要：目的探讨老年2型糖尿病患者胰岛素抵抗和胰岛β细胞功能的特点。方法测定30例老年2型糖尿病患者空腹血糖(FPG)、血清胰岛素(FNS)和C肽,计算HOMA-IR和胰岛素敏感指数(ISI)以评价胰岛素抵抗,以HOMA-β和C肽作为衡量胰岛β细胞功能指标,与10例健康老年人的相应指标作对比并进行分析。结果与对照组相比,老年2型糖尿病组的FPG、FNS和HO-MA-IR明显升高,而C肽I、SI和HOMA-β明显下降,其间差异有显著意义(P<0.05)。结论老年2型糖尿病患者存在明显的胰岛素抵抗和胰岛β细胞功能异常,同时可能伴有高胰岛素低C肽分离现象,提示胰岛素抵抗和胰岛β细胞功能异常是糖尿病患者糖代谢紊乱的主要原因。Objective To study the characteristics of insulin resistance and the function of islet cells in elderly patients with type 2 diabetes mellitus（T2DM）. Methods Fasting plasma glucose（FPG）, fasting serum insulin（FNS） and C-peptide were measured in 30 elderly patients with type 2 diabetes mellitus respectively. Homeostasis model assessment-insulin resistance index（HOMA-IR） and isulin sensitivity index （ISI） were applied to assess the status of insulin resistancy, HOMA-β was used to assess the basic function of isletfl cells. These values were compared with 10 healthy seniors. Results The level of Cpeptide and ISI and HOMA-flwere lower than in control group. There were very significant differences between T2DM group and the control group （P〈0. 05）. Conclusion Elderly patients with type 2 diabetes mellitus have obvious insulin resistance and islet cells dysfunction. Hyperisulinemia with low C-peptide level may exist in elderly patients with type 2 diabetes mellitus. This study suggests that insulin resistance and islet cells dysfunction may play a key role in glycometabolism disorder in elderly patient with type 2 diabetes mellitus.

关 键 词：2型糖尿病 血糖 C肽 胰岛素抵抗 Β细胞 

分 类 号：R587.1[医药卫生—内分泌] R592[医药卫生—内科学]