异构化法合成噻唑磷  

Fosthiazate synthesis by an isomerization method

作　　者：翁建全[1] 沈德隆[1] 谭成侠[1] 

机构地区：[1]浙江工业大学化学工程与材料学院,杭州310032

出　　处：《农药》2006年第8期527-528,共2页Agrochemicals

摘　　要：先将2-噻唑烷酮与O,O'-二乙基硫代磷酰氯进行缩合反应生成O,O'-二乙基-2-氧代-1,3-噻唑烷-3-基硫逐磷酸酯,该硫逐磷酸酯再与二甲胺反应生成相应硫代磷酸酯铵盐,然后与溴代仲丁烷进行烷基化反应得到噻唑磷。反应总收率达到36%,产品含量大于80%。产物结构经IR、1HNMR和MS表征。Fosthiazate was synthesized by condensing 2-thiazolidinone with O,O＇-diethylthio- phosphonochloride, and then alkylating the resulting O,O＇- diethyl-2-oxo-1,3-thiazolidine-3-thiophosphate with dimethylamine, followed by direct alkylation of the ammonium salt with 2-bromobutane. Total yield of fosthiazate was as high as 36% and product purity was 〉80%. The structure of the product was identified by IR, 1^H-NMR and MS.

关 键 词：异构化 2-噻唑烷酮 O O’-二乙基硫代磷酰氯 噻唑磷 合成 

分 类 号：TQ453[化学工程—农药化工]