地蜂子抗炎镇痛作用的实验研究  

Study on Anti-inflammatory and Analgesic Effect of Potentilla Freyniana Bornm

作　　者：肖本见[1] 陈国栋[1] 朱敏英[1] 梁文梅 

机构地区：[1]湖北民族学院医学院,445000 [2]湖北施恩堂制药有限公司

出　　处：《天津医药》2006年第7期482-484,共3页Tianjin Medical Journal

摘　　要：目的:探讨地蜂子的抗炎镇痛作用。方法:抗炎实验采用二甲苯致小鼠耳廓肿胀、角叉菜胶致大鼠足跖肿胀和大鼠棉球肉芽肿炎症模型;镇痛实验采用热板法和醋酸扭体法。结果:地蜂子水煎液灌胃100mL/(kg·d)能明显的抑制二甲苯致小鼠耳廓肿胀(P<0.05)。地蜂子醇提液腹腔注射2mL/kg在1h、2h、3h、4h时对角叉菜胶致大鼠足跖肿胀有非常明显的抑制作用(P<0.01)。水煎液腹腔注射2ml/kg对棉球埋藏引起的慢性肉芽肿有明显的抑制作用(P<0.01);在60min时对热板致小鼠痛阈有明显提高(P<0.01)。水煎液皮下注射2mL/kg、0.5mL/kg对醋酸致小鼠扭体反应有明显的抑制作用(P<0.01)。结论:地蜂子有明显的抗炎镇痛作用。Objective： To study the anti-inflammatory and analgesic effects of potentilla freyniana bornm. Methods： A few conventional models, such as the mouse pinna swelling induced by xylene; the rats hind paw swelling elicited by carrageenan, the rats proliferation of granuloma led by implanting cotton pellet was selected. Analyesia experiments adopted hot-plate procedure and the torsion body induced by acetum method. Results： The water extract （100 mL ·kg^-1·d^-1） of potentilla freyniana bornm lavaga obviously inhibited the swelling of mouse pinna induced by xylene （P 〈 0.05）, the potentilla freyniana bornm alcohol extract （2 mL/ kg） intraperitoneal injection suppressed the edema of rat hind paw swelling elicited by 1% carrageenan after 1 h,2 h,3 h,4 h （P 〈 0.01）; the water extract （2 mL/kg） intraperitoneal injection significantly depressed the increase of proliferation of granuloma led by implanting cotton pellet （P 〈 0.01）, the water extract had an increase of pain threshold effect induced by the hot-plate method after 60min （P 〈 0.01）; the water extract （2 mL/kg, 0.5 mL/kg） subcutaneous injection obviously inhibited the torsion body induced by acetum （P 〈 0.01）. Conclusion： Potentilla freyniana bornm is an effective medicine on anti-inflammation and analgesia.

关 键 词：抗炎剂(中药) 民族药 止痛药(中药) 炎症 

分 类 号：R971.1[医药卫生—药品] R259.125[医药卫生—药学]