较大剂量美托洛尔片治疗老年不稳定心绞痛的药物不良反应观察  

Observation of the adverse effects incurred from lower heart rate by large dose moteprolol tablet in the elderly patients with unstable angina pectoris

作　　者：刘丰[1] 黄为民[1] 张莉[2] 李庆云[1] 吴剑芸[1] 邢植斐[1] 

机构地区：[1]广州市第一人民医院老年病科,广东广州510180 [2]增城市人民医院心内科

出　　处：《中国临床药理学杂志》2006年第3期230-232,共3页The Chinese Journal of Clinical Pharmacology

基　　金：广州市科委"九五"科技攻关重点资助项目(99-Z-102-6)

摘　　要：目的探讨较大剂量美托洛尔(抗心绞痛药)治疗老年不稳定心绞痛 (UAP)心率减低时,可能出现的药物不良反应。方法 139例UAP患者,分为A、B 2组,A组(69例)用美托洛尔每日174 mg,心率:每分53次;B组(70 例)用美托洛尔,每日131 mg,心率:每分60次。分别观察1年内2组在心血管、代谢、中枢神经、肾功能等方面的药物不良反应。结果 2组均未发生因心律失常、低血压而停药者;但因心率而疑虑者A组为26人(38％),B组为 11人(15％),2组经较差异显著。A组糖尿病调整剂量者为3例,B组为0; A组餐后血糖升高者为4例,B组为1例,差异均不显著。A组体重增加者2 例,B组为0。结论用较大剂量美托洛尔,使心率每分53次较心率60次, 无明显副作用增加。Objective To observe the adverse reaction incurred from lower heart rate by large dose metoprolol in the elderly patients with unstable angina pectoris（UAP）. Methods One hundred and thirty- nine cases were divided into two groups （A,69 cases） ：the heart rate was 53 beats·min^-1,the metoprolol was used 174 mg once daily,while B group （ 70 cases）： the heart rate was 60 beats·min^-1, metoprolol was used 131 mg once daily. The adverse effects of two groups focused in cardiovascular system, metabolism, center nerves system, renal function were observed. Results There was no patient to withdrawal the drug because the adverse reaction of arrhythmia and hypotension in two groups. But there was significantly difference in worrying about the low heart rate, A group 26 cases（38% ） versus B group llcases（ 15% ）. There were no significantly differences in changing dosage because the diabetes（3 cases in A group versus 0 in B group）, elevating in postprandial blood sugar（4 cases in A group versus 1 case in B group） ,weight gaining （2 cases in A group versus 0 in B group）and another adverse reaction. Conclusion The adverse reaction did not increase when the heart rate decreased from 60 to 53 beats· min^-1 with large dose metoprolol.

关 键 词：心绞痛 药物不良反应 美托洛尔片 

分 类 号：R541.4[医药卫生—心血管疾病] R972.3[医药卫生—内科学]