莫达非尼治疗脊髓灰质炎后患者疲劳的随机对照试验  

Randomized controlled trial of modafinil for the treatment of fatigue in postpolio patients

作　　者：Strohschein F.J. Rydz D. 田雨灵 

机构地区：[1]Division of Physical Medicine and Rehabilitation, 513 Heritage Medical Research Centre, University of Alberta, Edmonton, Alta. T6G 2S2, Canada

出　　处：《世界核心医学期刊文摘（神经病学分册）》2006年第6期49-49,共1页Digest of the World Core Medical Journals:Clinical Neurology

摘　　要：The purpose of this study was to test whether modafinil is effective in alleviating the symptoms of fatigue in postpolio patients, because it has been helpful for such symptoms in other neurologic disorders. Using a double-blind, randomized, placebo-controlled cross-over design, 14 postpolio patients with moderate to severe fatigue were assigned to receive modafinil or placebo first. Piper Fatigue Scale, Epworth Sleepiness Scale, digit span, and reaction time tests were done at baseline and then at weekly intervals. The Piper Fatigue Scale scores im proved by 27 ±40%(mean ±SD) following modafinil and by 43 ±36%following pla cebo. Scores for most of the other tests did not change during the study. Therefore, we conclude that modafinil was not effective in alleviating the symptoms of fatigue in postpolio patients.The purpose of this study was to, test whether modafinil is effective in alleviating the symptoms of fatigue in postpolio patients, because it has been helpful for such symptoms in other neurologic disorders. Using a double-blind, randomized, placebo-controlled cross-over design, 14 postpolio patients with moderate to severe fatigue were assigned to receive modafinil or placebo first. Piper Fatigue Scale, Epworth Sleepiness Scale, digit span, and reaction time tests were done at baseline and then at weekly intervals. The Piper Fatigue Scale scores improved by 27 ±40% （mean ＋SD） following modafinil and by 43 ±36% following placebo. Scores for most of the other tests did not change during the study. Therefore, we conclude that modafinil was not effective in alleviating the symptoms of fatigue in postpolio patients.

关 键 词：脊髓灰质炎 安慰剂治疗 随机对照试验 疲劳症状 莫达非尼 患者 神经系统疾病 量表评分 睡眠量表 交叉设计 

分 类 号：R512.4[医药卫生—内科学] R473.73[医药卫生—临床医学]