产ESBLs大肠埃希菌和肺炎克雷伯菌的检测及耐药性分析  

A Survey on Escherichia coli and Klebsiella Pneumoniae Produceing the ESBLs

作　　者：艾彪[1] 马青[1] 涂少军[1] 李琦[1] 边藏丽[2] 

机构地区：[1]长江大学附属第一人民医院,湖北荆州434000 [2]长江大学医学院,湖北荆州434000

出　　处：《长江大学学报（自科版）（下旬）》2006年第2期264-266,共3页Journal of Yangtze University

摘　　要：目的：检测临床标本中产ESBLs大肠埃希菌和肺炎克雷伯菌，分析其耐药性。为指导临床合理地选用抗菌素提供可靠的依据。方法：用VITEK-32型全自动细菌分析系统进行细菌鉴定、药敏试验和ESBLs测定。结果：产ESBLs大肠埃希菌为43．1％．产ESBLs肺炎克雷伯菌为19．4％；2种产ESBLs菌对氢苄西林、头孢唑林等7种抗生素的耐药率为100％，对头孢吡肟、环丙沙星等8种抗生素耐药率为54．5％～85．7％，而对亚胺培南敏感未出现耐药现象。结论：临床标本产ESBLs大肠埃希菌和肺炎克雷伯菌检出率较高，应限制广谱β-内酰胺类抗生素特别是第三代头孢菌素的使用；亚胺培南可作为治疗产ESBLs菌严重感染的首选药物。ESBLs；大肠埃希菌；肺炎克雷伯菌；Objective: To examine the Escherichia coli and Klebsiella pneumoniae producing the ESBLs,and analyze their ability to drug resistance,in order to provide issues for guiding clinic to choose antibiotics reasonably.Methods: Use fully-automatic germ analysis system——VITEK-32 for germ identification,drug sensitivity test and ESBLs germs'determination.Results: In the experiment,the positive percent of the Escherichia coli and Klebsiella pneumoniae which produce the ESBLs was respectively 43.1%and 18.9%,at the same time,their drug tolerance rate for resisting 7 kinds of antibiotics such as ampicillin,cefazolin and so on was 100%,and the rate for resisting 8 kinds of antibiotics such as cefepime,ciprofloxacin and so on were from 54.5% to 85.7%.But they didn't resist imipenem during the experiment.Conclusion: The positive rate of the Escherichia coli and Klebsiella pneumoniae producing the ESBLs is high,we recommend avoiding the use of wide containingβ-lactamas antibiotics especially cephalosporins of the third generation.As the germs producing the ESBLs are sensitive to imipenem,the imipenem can be used as a preferred medicine curing the severe diseases infected by the germs producing the ESBLs.

关 键 词：ESBLs大肠埃希菌 肺炎克雷伯菌 耐药性 

分 类 号：R378.99[医药卫生—病原生物学]