全氟丙烷白蛋白微球注射剂左心声学造影的初步临床观察  

Left Heart Contrast Echo Enhanced Resolution of Ventricular Endocardium by Perfluoropropane-albumin Microsphere Injection:A Prelimilary Clinical Trial

作　　者：吕静[1] 吕清[2] 郑智超[2] 王新房[2] 谢明星[2] 卢晓芳[2] 杨亚利[2] 王静[2] 贺林[2] 

机构地区：[1]湖北省江汉油田总医院超声科,湖北潜江433124 [2]华中科技大学同济医学院协和医院超声影像科,湖北武汉430022

出　　处：《长江大学学报（自科版）（下旬）》2006年第2期267-269,278,共4页Journal of Yangtze University

摘　　要：目的:评价全氟丙烷白蛋白微球注射剂经静脉注射后增强左室内膜边界识别的效果。方法:50例研究对象分别经静脉注射稀释的全氟丙烷白蛋白微球注射剂0.01 mL/kg,采用自身前后对照方法,评价左室显影和左室内膜边界识别的效果。结果:50例研究对象注射全氟丙烷白蛋白微球注射剂后,左室内膜边界可清晰识别节段数明显增多,两独立研究者间结果无统计学差异。A研究者评价结果:左心室显影II级占2%,III级占98%;B研究者评价结果:左心室显影II级占4%,III级占96%。两组研究者分别独立评价的造影有效率均为100%,差异无统计学意义。结论:全氟丙烷白蛋白微球注射剂经静脉注射后左心显影效果显著。Objective:A clinical study was carried out to evaluated the effect of perfluoropropane-albumin microsphere injection on the left ventricular echo enhancement.Methods:The left heart contrast echocardiography,using intravenous bolus injection of perfluoropropane-albumin microsphere contrast agent,were performed in the 50 patients.Observer A and observer B evaluated the contrast effect respectively by self-comparison between pre-injection and post-injection.Results:Both observers considered the number of clearly recognized endocardial border segments increased significantly.The difference between them is no of significance(P>0.05).Observer A had a result that in 2% patients the LV endocardial border enhancemen of left ventricular reached Grade Ⅱ and in 98% patients reached grade Ⅲ,while observers B had a result that in 4% patients that reached grade Ⅱ and in 96% patients reached grade Ⅲ.The results between two observers had no significant difference(P>0.05).Conclusion:perfluoropropane-albumin microsphere injection could enhance the resolution of left ventricular endocardium.

关 键 词：超声心动图 造影剂 临床试验 全氟丙烷白蛋白微球 

分 类 号：R445.14[医药卫生—影像医学与核医学]