天然产物Epibatidine的作用受体初探  

Studies on Action Receptor to Natural Product Epibatidine

作　　者：徐建平[1] 何东 王志中 沈家骢[1] 高连勋[1] 宋雅茹 

机构地区：[1]吉林大学化学系,中国科学院长春应用化学研究所,北京师范大学化学系

出　　处：《高等学校化学学报》1996年第11期1742-1743,共2页Chemical Journal of Chinese Universities

基　　金：吉林省科学技术委员会青年基金

摘　　要：天然产物Ｅｐｉｂａｔｉｄｉｎｅ的作用受体初探徐建平，何东，王志中，沈家骢，高连勋，宋雅茹（吉林大学化学系，理论化学研究所，长春，１３００２３）（中国科学院长春应用化学研究所）（北京师范大学化学系）关键词Ｅｐｉｂａｔｉｄｉｎｅ，尼古丁，受体，ＡＭ１１９...According to the theoretical calculation of epibatidine and nicotine by using AM1 method,we made a good explaination for the phenomenon that the analgetic action of epibatidine doesn't be reversed by naloxone as usual analgetics for the first time,and this result supports the results of Daly's experiment.In addition,as epibatidine and micotine have many similarities such as structure,activity and other qualities,so we believe that they also have the same action receptor-nicotine receptor.

关 键 词：EPIBATIDINE 尼古丁 受体 生物碱 天然产物 

分 类 号：O629.3[理学—有机化学]