冻干水痘减毒活疫苗免疫持久性观察  

Immune Persistence of Freeze-dried Live Attenuated Varicella Vaccine

作　　者：刘晔[1] 高嵩[1] 赵军[1] 王鹏[1] 徐俊峰[1] 李莉[1] 徐秀凤[1] 李占春[1] 哈秀杰[1] 李开军[1] 刘延威[1] 王丽华[1] 宣黎波[1] 王立成[1] 王连成[1] 

机构地区：[1]长春生物制品研究所有限公司,长春130012

出　　处：《中国生物制品学杂志》2006年第4期420-422,共3页Chinese Journal of Biologicals

摘　　要：目的 观察国产冻干水痘减毒活疫苗的免疫原性和免疫持久性。方法 选免疫前抗体阴性的健康易感儿童，随机分为3组，分别接种原倍疫苗、稀释疫苗及对照疫苗，并于接种后每年采集静脉血，用FAMA法测定抗体。结果 原倍疫苗组和稀释疫苗组免疫后1～5年，平均抗体阳性率分别为91．05％、89.39％、95．56％、97．27％和98.76％。免疫后1年与5年抗体阳性率及抗体GMT比较，差异均无显著意义。原倍疫苗组和稀释疫苗组抗体阳性率及抗体GMT比较，差异亦无显著意义。接种原倍和稀释疫苗的两组与对照组比较，差异无显著意义。结论 国产冻于水痘减毒活疫苗具有良好的免疫原性及免疫持久性。Objective To observe the immune persistence of domestic freeze-dried live attenuated varicella vaccine in volunteers. Methods Divide varicella antibody negative healthy children into three groups. Immunize the children in two trial groups with original and diluted domestic freeze-dried live attenuated varicella vaccine, and those in control group with imported varicella vaccine. Collect the intravenous blood of each group annually for 5 years for determination of antibody by FAMA. Results The mean antibody positive rates of two trial groups 1,2,3,4 and 5 years after immunization were 91.05% ,89.39% ,95.56% ,97.27% and 98.76% respectively. No significant difference was observed between the antibody positive rates or GMTs 1 and 5 years after immunization. Besides this,the antibody positive rates and GMTs showed no significant difference between the two trial groups,and between the trial and control groups. Conclusion Domestic freeze-dried live attenuated varicella vaccine showed good immunogencity and immune persistence.

关 键 词：冻干水痘减毒活疫苗 免疫持久性 抗体阳性率 GMT 

分 类 号：R511.5[医药卫生—内科学] R186[医药卫生—临床医学]