单剂量冰片及单剂量复方制剂中冰片的药物动力学比较研究  

Comparative Study of the Pharmacokinetics of Borneolum Syntheticum and Borneol in Herbal Preparations

作　　者：黄天来[1] 叶少梅[1] 欧卫平[1] 宓穗卿[1] 

机构地区：[1]广州中医药大学临床药理研究所,广州510405

出　　处：《中药新药与临床药理》2006年第4期265-267,共3页Traditional Chinese Drug Research and Clinical Pharmacology

基　　金：国家自然科学基金课题(39770909)

摘　　要：目的比较研究冰片和复方丹参滴丸中的冰片在大鼠体内的药物动力学。方法大鼠单剂量灌服冰片、含等量冰片的复方丹参滴丸,应用GC-MS、GC-FID测定药后一系列时间点冰片的血中浓度。应用PKSolu2.0药物动力学软件(USA)处理药-时曲线数据,求得冰片的药物动力学参数。结果等剂量的冰片和复方丹参滴丸中的冰片的药物动力学参数有显著差异,单味冰片的吸收相,分布相及清除相的速率常数分别为2.630h-1,1.788h-1及0.273h-1,远大于复方丹参滴丸中等量冰片相应的速率常数(1.635h-1,0.784h-1和0.116h-1)。单味冰片的达峰时间(0.5h)早于复方丹参滴丸(0.75h),但峰浓度16.8μg/mL约为复方丹参滴丸的l/2(31.02μg/mL),药后18h的浓度(0.043μg/mL)约为复方丹参滴丸的l/10。结论中药(复方)药物动力学研究中应注意其他成分(组成)对所研究(观察)成分药物动力学的影响。Objective To compare the pharmacokinetics of bomeolum syntheticum（BS） and bomeol in compound Danshen dropping pills in rats. Method Rats were administrated orally with BS or Danshen dropping pills containing equal amount of bomeol in a single dose. The blood contents of bomeol at a series of time points were assayed by GC - MS and GC - FID after administration, The drug - time curve was estimated by PK Solution 2.0 pharmacokinetic software （ USA ）. Results The pharmacokinetic parameters are quite different between the single dose of BS and the borneol in the compound Danshen dropping pills： the velocity constants of absorption（ 2, 630h^-1）, distribution （ 1. 788 h^-1） and elimination（0. 273 h^-1） of BS were much greater than those （ 1.635h^-1, 0. 784h^-1, 0. 116h^-1） of the same quantity of borneol in compound Danshen dropping pills, while the Tmax （0, 5 h） of former was shorter than that （0. 75 h） in the latter, and the Cmax （ 16. 8μg/mL） in the former was about half of the latter （31.02μg/mL）, And, at the 18h after administration, the former blood concentration（ 0. 043μg/mL） was approximately one tenth of the latter. Conclusion It is suggested that we should pay attention to the influence of other ingredients on the main objective component in the study of pharmacokinetics of compound traditional chinese drug.

关 键 词：冰片 复方丹参滴丸 GS—MS 药物动力学 

分 类 号：R285.5[医药卫生—中药学]