不同透皮促进剂对复方麻黄贴剂中麻黄碱透皮吸收的影响  

Effects of Different Transdermal Enhancers on Percutaneous Absorption of Ephedrine in Compound Herba Ephedrae Adhesive Plaster

作　　者：潘林梅[1] 沈静[1] 郭立玮[1] 

机构地区：[1]南京中医药大学植物药深加工工程中心,南京210029

出　　处：《中药新药与临床药理》2006年第4期286-287,共2页Traditional Chinese Drug Research and Clinical Pharmacology

摘　　要：目的研究不同透皮促进剂对中药复方麻黄贴剂中麻黄碱的透皮吸收的影响。方法采用改良Franz扩散池装置,运用HPLC法对麻黄碱进行含量测定,对不同透皮促进剂的促渗效果进行考察。结果氮酮单独使用或与其他促渗剂混合使用,渗透促进效果均较佳,说明氮酮在促进麻黄碱的渗透过程中起主导作用。氮酮和丙二醇合用体外透皮速率K可达94.280μg·cm-2·h-1。结论氮酮与丙二醇合用可促进麻黄碱的透皮吸收,可作为本复方的透皮促进剂。Objective To investigate the effect of different transdermal enhancers on percutaneous absorption of ephedrine in Compound Herba Ephedrae Adhesive Plaster. Methods Using modified Franz diffusion cell, the ephedrine content was determined to investigate the effect of different transdermal enhancers in promoting percutaneous absorption. Results Azone or azone used together with other transderml enhancers had a better effect in promoting percutaneous absorption, indicating that azone was the leading transderml enhancers for ephedrine. The mixed transdermal enhancer of azone and propylene glycol was the most effective combination and the rate constant of percutaneous absorption is 94. 280μg·cm^-2·h^-1. Conclusion The mixture of azone and propylene glycol can enthance the percutaneous absorption of ephedrine and can be used as the transdermal enhancers for this compound piaster.

关 键 词：复方麻黄贴剂 麻黄碱 透皮促进剂 透皮吸收 

分 类 号：R284.2[医药卫生—中药学]