试析穿心莲片中穿心莲内酯及脱水穿心莲内酯的变异因素  

Influence of Processing Technology on Andrographolide and Dehydroandrographolide Contents in Andrographis Tablet

作　　者：曾惠芳[1] 黄晓丹 苏子仁[1] 陈建南[1] 赖小平[1] 

机构地区：[1]广州中医药大学,广州510405 [2]广州王老吉药业股份有限公司,广州510450

出　　处：《中药新药与临床药理》2006年第4期299-302,共4页Traditional Chinese Drug Research and Clinical Pharmacology

基　　金：广州市科技攻关计划--科技攻关引导项目(2003z3-E5011)

摘　　要：依据穿心莲内酯、脱水穿心莲内酯的稳定性机理,从药材原料(产地、采收季节、贮藏时间)、热稳定性、生产工艺(溶媒、温度、受热时间、贮藏条件)等方面分析穿心莲制剂过程中影响穿心莲内酯、脱水穿心莲内酯含量的因素,探讨提高穿心莲片质量的措施。结果表明,优选穿心莲药材,优化制剂工艺,降低加热时间和温度,均是提高穿心莲片质量的有效措施。On the basis of thermal stability of andrographolide and dehydroandrographolide,the influences of medicinal material factors(habitats,collecting time,storage time),thermal stability,production technology(solvent,temperature,heating time and storage condition)on the content of andrographolide and dehydroandrographolide in Andrographis Tablet(AT)were explored so as to increase the quality of AT.The results showed that the excellent medicinal material of Herba Andrographis,optimized production technology,shorter heating time and lower temperature are the effective measures for increasing the quality of AT.

关 键 词：穿心莲片 穿心莲内酯 脱水穿心莲内酯 热稳定性 制剂工艺 质量 

分 类 号：R284.2[医药卫生—中药学]