稳定性心绞痛伴冠状动脉完全闭塞患者血浆各种生长因子水平与冠状动脉侧支循环程度的关系  

Relation of various plasma growth factor levels in patients with stable angina pectoris and total occlusion of a coronary artery to the degree of coronary collaterals

作　　者：Briguori C. Testa U. Colombo A. 姜朝晖(译) 任付先(校) 

机构地区：[1]Department of Cardiology, Clinica Mediterranea, Federico II University, Naples, Italy [2]不详

出　　处：《世界核心医学期刊文摘（心脏病学分册）》2006年第6期34-34,共1页

摘　　要：We assessed(1) angiogenic factors in patients with stable angina and longstanding(< 24 months) total occlusion of a single coronary artery and(2) the relation between plasma levels of angiogenic factors and the development of collateral vessels as evaluated by coronary angiography. Plasma concentrations of vascular endothelial growth factor(VEGF165), fibroblast growth factor, placenta- derived growth factors(PlGFs), and hepatocyte growth factor were assessed in 96 patients with stable angina and longstanding(< 24 months) total occlusion of a single coronary artery. According to coronary angiographic results, 18 patients had no visible collaterals(group 0), 21 patients had visible collaterals but no filling of the recipient epicardial vessel(group 1), and 57 patients showed filling(partial or complete) of the recipient epicardial vessel by collaterals(group 2). Plasma VEGF165 and PlGF concentrations were higher in group 1 than in groups 0 and 2(VEGF165 75 pg/ml, range 24 to 105, vs 23 pg/ml, range 15 to 29, and 19 pg/ml, range 10 to 41, respectively, F=5.53, p=0.006; PlGF 35 pg/ml, range 3.5 to 105, vs 1 pg/ml, range 1 to 38, and 1 pg/ml, range 1 to 5, respectively, F=7.09, p=0.008). Plasma VEGF165 and PlGF levels were similar in groups 0 and 2. There was no significant difference in plasma levels of fibroblast and hepatocyte growth factor concentrations across the 3 groups. In conclusion, plasma levels of angiogenic growth factors differ among patients with stable angina pectoris and longstanding total coronary occlusion.We assessed（1） angiogenic factors in patients with stable angina and longstanding（ 〈 24 months） total occlusion of a single coronary artery and（2） the relation between plasma levels of angiogenic factors and the development of collateral vessels as evaluated by coronary angiography. Plasma concentrations of vascular endothelial growth factor （VEGF165）, fibroblast growth factor, placenta-derived growth factors（PIGFs）, and hepatocyte growth factor were assessed in 96 patients with stable angina and longstanding （ 〈 24 months） total occlusion of a single coronary artery. According to coronary angiographic results, 18 patients had no visible collaterals（group 0）, 21 patients had visible collaterals but no filling of the recipient epicardial vessel （group 1）, and 57 patients showed filling（partial or complete） of the recipient epicardial vessel by collaterals （group 2） .

关 键 词：冠状动脉侧支循环 冠状动脉完全闭塞 血管内皮生长因子 稳定性心绞痛 患者血浆 成纤维细胞生长因子 肝细胞生长因子 侧支血管 水 冠状动脉造影 

分 类 号：R541.4[医药卫生—心血管疾病] R543.3[医药卫生—内科学]