饮食补充ω-3脂肪酸对慢性心力衰竭患者内皮依赖性血管舒张功能的影响  

Effects of dietary omega-3 fatty acid supplementation on endothelium-dependent vasodilation in patients with chronic heart failure

作　　者：Morgan D.R. Dixon L.J. Hanratty C.G. 柴大军 

机构地区：[1]Department of Therapeutics and Pharmacology, Queen's University Belfast, Belfast, United Kingdom Dr.

出　　处：《世界核心医学期刊文摘（心脏病学分册）》2006年第6期41-42,共2页

摘　　要：We investigated the effects of omega- 3 fatty acids administration on endothelium- dependent vasodilation in patients< 65 years old who received treatment for chronic heart failure(CHF). Twenty patients(mean age 73 years; 15 men) with grade II and III CHF who were on maximal medical management were recruited. Patients were randomized in a double- blind, crossover fashion to 6 weeks of omega- 3 fatty acid(1.8 g ecosapentaenoic acid and 1.2 g docosahexaenoic acid) or olive oil. Forearm blood flow(FBF) responses to incremental doses of intra- arterial sodium nitroprusside, acetycholine(ACH), angiotensin- II, and Ng- nitro-l- arginine methyl ester were assessed by venous occlusion strain gauge plethysmography. The endothelium- dependent increase in FBF was greater in response in ACH infusion after omega- 3 fatty acid administration(7.9, 95% confidence interval [CI] 4.81 to 11.08 to 11.3, 95% CI 7.31 to 15.23 arbitrary units(p< 0.05) compared with baseline(7.95, 95% CI 4.8 to 11.08 arbitrary units) and olive oil administration(7.27, 95% CI 4.66 to 9.88 arbitrary units)(p=NS for both). Neither omega- 3 fatty acid nor olive oil altered endothelium- independent vasodilation in response to infusion of sodium nitroprusside, nor did they influence vasoconstrictor responses to angiotensin- II or Ng- nitro- l- arginine methyl ester. Dietary omega- 3 fatty acid supplementation was accompanied by an increase in FBF response to ACH, which represents enhanced endothelium- dependent vasodilation in CHF. Further studies are warranted to assess the mechanism responsible for the beneficial actions of omega- 3 fatty acids in CHF.We investigated the effects of omega-3 fatty acids administration on endothelium-dependent vasodilation in patients 〈 65 years old who received treatment for chronic heart failure（CHF） . Twenty patients（mean age 73 years; 15 men） with grade Ⅱ and Ⅲ CHF who were on maximal medical management were recruited. Patients were randomized in a double-blind, crossover fashion to 6 weeks of omega-3 fatty acid（1.8 g ecosapentaenoic acid and 1.2 g docosahexaenoic acid） or olive oil. Forearm blood flow （FBF） responses to incremental doses of intra-arterial sodium nitroprusside, acetycholine （ACH）, angiotensin-Ⅱ, and Ng-nitro-1-arginine methyl ester were assessed by venous occlusion strain gauge plethysmography. The endothelium-dependent increase in FBF was greater in response in ACH infusion after omega-3 fatty acid administration（7.9, 95% confidence interval [CI] 4. 81 to 11.08 to 11.3, 95% CI 7.31 to 15.23 arbitrary units（p 〈0. 05） compared with baseline（7.95, 95% CI 4. 8 to 11.08 arbitrary units） and olive oil administration（7.27, 95% CI 4.66 to 9.88 arbitrary units） （p = NS for both） .

关 键 词：内皮依赖性血管舒张功能 慢性心力衰竭患者 Ω-3脂肪酸 饮食补充 乙酰胆碱(ACH) 慢性心力衰竭(CHF) L-精氨酸甲酯 药物治疗 血管紧张素Ⅱ 平均年龄 

分 类 号：R541.4[医药卫生—心血管疾病] R541.61[医药卫生—内科学]