反式翻译模型  

A Model for Trans-translation

作　　者：周海燕[1] 吴永尧[1] 陈建红[1] 曾分有[1] 田云[1] 

机构地区：[1]湖南农业大学生化与发酵工程实验室,长沙410128

出　　处：《遗传》2006年第8期1051-1054,共4页Hereditas（Beijing)

摘　　要：反式翻译是细菌体内一种修复翻译水平上受阻的遗传信息表达过程的机制。tmRNA是反式翻译的核心分子,它兼具tRNA和mRNA的特点,在SmpB蛋白的帮助下特异性识别携带mRNA缺失体的核糖体,在核糖体蛋白S1的传递作用下结合在A位点上,一方面延续被中断的mRNA上的遗传信息,一方面终止蛋白质的合成,释放被束缚的核糖体和tRNA进入新的翻译过程。文章对近年来关于反式翻译模型的研究进行综述。Trans-translation is a mechanism that fixes stalled translation course, tmRNA is the core of trans-translation and it has dual function as a tRNA and a mRNA. tmRNA recognizes the ribosome carrying truncated mRNA with specificity under the help SmpB protein. It can be directed to A site by ribosomal protein S1. At first tmRNA prolongs the genetic message on the stalled mRNA, then termination codon stops peptide synthesis to form a nascent chain with the tag sequence. Finally, tmRNA-SmpB system frees stalled ribosomes and directs degradation of the products of these frus trated protein synthesis reactions. This paper introduces the most recent studies on trans-translation.

关 键 词：反式翻译 TMRNA SmpB蛋白 核糖体蛋白S1 

分 类 号：Q933[生物学—微生物学]