预防用药对激素性股骨头血流量和血液流变学的影响  

Preventive Effect of Drugs on Hemorheology and Blood Flow of Hormonal Necrosis of Femoral Head

作　　者：李景田[1] 邹锦慧[2] 吉燕翔[3] 张慧明[2] 周小璜[1] 李伯灵[1] 陈秀琴[1] 林拓[3] 

机构地区：[1]韶关学院医学院药理学教研室 [2]韶关学院医学院解剖教研室,广东韶关512026 [3]广东省粤北人民医院核医学科,广东韶关512026

出　　处：《中国血液流变学杂志》2006年第2期178-181,共4页Chinese Journal of Hemorheology

基　　金：广东省韶关市科技信息局科研基金项目(2004-37)

摘　　要：目的探讨应用药物预防激素性股骨头坏死。方法给予类固醇激素,诱导出兔股骨头坏死动物模型,同时使用血塞通、脂必妥和阿仑膦酸钠治疗,观察血液流变学指标和股骨头血流量。结果该方法可增加模型动物股骨头血流量,改善血液流变学指标,其增加或改善幅度与激素组相比有显著差异(P<0．05)。结论在长程使用类固醇激素同时应用血塞通、脂必妥和阿仑膦酸钠可提高股骨头血流量,改善血液流变学指标预防或减缓激素性股骨头坏死。Objective To study constervation prevent of experimental necrosis of femoral head.Methed On the basis of successfully induced rabbit models of femoral head necrosisf-using the Zhibituo and Panax notoginseng saponins and Alenduonate to treat the rabbit,and then,bone blood flow of femoral head and hemorheology index was observed.Result Zhibituo and Panax notoginseng saponins and Alenduonate given at the same time immediately could signifignantly improve the blood rheology and increase bone blood flow in comparison with hormone group （P〈0.05）.Conclusion The Zhibituo and Panax notoginseng saponins and Alenduonate may prevent steroidinduced necrosis of femoral head.

关 键 词：糖皮质激素 股骨头坏死 放射性微球技术 血液流变学 预防 

分 类 号：R965[医药卫生—药理学] R634[医药卫生—药学]