川崎病心肌损伤的检测  

Detection for Myocardial Damage in Kawasaki Disease

作　　者：李小彩[1] 常永超[1] 张诺芳 

机构地区：[1]河南科技大学第一附属医院,河南洛阳471003 [2]河南开封儿童医院,河南开封470000

出　　处：《中国血液流变学杂志》2006年第2期263-264,共2页Chinese Journal of Hemorheology

摘　　要：目的探讨血清心肌肌钙蛋白I(cTnI)诊断川崎病(KD)急性期心肌损伤的临床价值。方法测定治疗前 (急性期)血清cTnI及CK-MB水平和不同方法治疗后两者的水平变化。结果①KD急性期cTnI、CK-MB的阳性率均较高,且两者相比有显著差异(P<0．05)。②免疫球蛋白(IVIG)治疗与非IVIG治疗cTnI和CK-MB的阳性率均有显著差异(P<0．05)。结论 cTnI、CK-MB对KD患儿急性期心肌损伤均有诊断价值;两者相比,cTnI具有更高特异性、敏感性。CTnI可作为指导临床应用IVIG和动态评定疗效的指标。Objective To explore the clinical significance of serum cardiac troponin （cTnⅠ） for the detection of myocardial injury in children with Kawasaki disease （KD） in acute stage. Methods The level of serum cTnl and creatine kinase iso-enzyme （CK-MB） were determined in 68 children with KD before treated and after treated with different means. Results （1） The level of serum cTnI and CK-MB in acute stage with KD were higher than normal, and there was significant difference in the positive rate between serum cTnI and CK-MB （P〈0.05）. （2）There was significant difference in the positive rates of serum cTnI and CK-MB after the treatment with WIG and no （P〈0.05）. Conclusion The determination of cTnI and CK- MB will be available for the diagnosis of myocardial injury in children with KD in acute stage and the determination ofcTnI is more sensitive and specific compared with CK- MB; cTnI can be used as an index to use IVIG and to evaluate the effect of the treatment with IVIG.

关 键 词：川崎病 心肌损伤 心肌肌钙蛋白I 

分 类 号：R725.9[医药卫生—儿科]