采用离心造粒工艺制备舒胸微丸的研究  

Preparation of Shuxiong micropellets by centrifugal granulation technology

作　　者：宋洪涛[1] 张倩[2] 康鲁平[1] 陈大为[2] 何仲贵[2] 

机构地区：[1]南京军区福州总医院药剂科,福建福州350025 [2]沈阳药科大学药学院,辽宁沈阳110016

出　　处：《中国中药杂志》2006年第14期1147-1150,共4页China Journal of Chinese Materia Medica

基　　金：国家自然科学基金资助项目(30200363);辽宁省博士启动基金资助项目(2001102042)

摘　　要：目的：制备舒胸微丸。方法：采用离心造粒法，以微丸粒径分布、休止角、松密度、脆碎度等为指标考察了影响微丸成型过程的处方因素和工艺因素。结果：微丸成丸的优化处方和工艺参数为：舒胸精制中间品与微晶纤维素（MCC）比例为3：1，黏合剂为3％羟丙基甲基纤维素（HPMC，5mPa·s），主机转速为200r·min^-1，鼓风流量为15×20L·min^-1，喷气流量为15L·min^-1，喷气压力为0．5Mp，喷浆泵转速为5-25r．min^-1，供粉机转速为5-25r．min^-1。结论：在优化条件下采用离心造粒法可制得表面较为光滑、圆整度较高的舒胸微丸，18-24目微丸的收率达90．5％。Objective： To prepare shuxiong micropellets. Method： Shuxiong micropellets were prepared by using a centrifugal granulator. The formulation composition and process factors were optimized investigated by adopting several indices such as size distribution, repose angle, bulk density and friability as indexes. Result： The optimal process parameters were as follows. The ratio of fine intermediate product and MCC was 3： l（w/w）, the adhesive agent was 3% HMPC solution, the rotating rate of plate was 200 r.min^-l , the blower rate was 15×20 L· min^-l, the rate of air flow was 15 L· min^-l, the spray air pressure was 0.5 MPa, the rotating of spray solution pump was 5-25 r·min^-l and the rotating rate of powder feed machine was 5-25 r· min^-1 Conclusion： Under the optimal conditions, micropellets prepared by using centrifugal granulator hadposessed prefect shape and surface characteristics and the yield of shuxiong pellets was 90.5 %.

关 键 词：舒胸微丸 离心造粒 制备 

分 类 号：TQ461[化学工程—制药化工]