N-取代苯基-2-取代-1,3-噻唑烷-3-甲酰胺的合成、结构及生物活性  

Synthesis, Structure and Biological Activities of N-Arylaminocarbonyl-2-oxo/thio-thiazolidine

作　　者：翁建全[1] 沈德隆[1] 谭成侠[1] 欧晓明 

机构地区：[1]浙江工业大学化学工程与材料学院,杭州310032 [2]国家南方农药创制中心湖南基地生测部,长沙410007

出　　处：《有机化学》2006年第8期1106-1110,共5页Chinese Journal of Organic Chemistry

基　　金：浙江省教育厅基金(No.20030145)资助项目.

摘　　要：为了寻找新的含噻唑杂环的先导化合物,利用2-取代-1,3-噻唑烷与取代苯基异氰酸酯在三乙胺催化下发生偶合反应,合成了17个N-取代苯基-2-取代-1,3-噻唑烷-3-甲酰胺化合物3,并利用1HNMR,IR,MS和元素分析对其结构进行了表征.用X-ray单晶衍射测定了N-苯基-2-氧代-1,3-噻唑烷-3-甲酰胺(3a)的晶体结构.初步生物活性试验结果表明,在试验浓度下部分目标化合物具有一定的杀菌和杀虫活性.In order to find new thiazole-heterocycle lead compounds, seventeen N-arylaminocarbonyl-2-oxo/thio-thiazolidine derivatives were synthesized from a coupling reaction of 2-oxo/thio-thiazolidine and aryl isocyanates catalyzed by Et3N. Their structures were confirmed by 1H NMR, IR, MS spectra and elemental analysis. The crystal structure of N-anilinocarbonyl-2-oxothiazolidine was determined by X-ray diffraction analysis. The preliminary bioassay showed that some of them exhibited certain fungicidal and insecticidal activities.

关 键 词：2-取代-1 3-噻唑烷 取代苯基异氰酸酯 合成 结构 生物活性 

分 类 号：TQ450.1[化学工程—农药化工]