含甲硫基和肟醚基的N-甲氧基氨基甲酸酯类化合物的合成及生物活性研究  

Synthesis and Bioactivity of N-Methoxylcarbamates Containing Methylthio and Oxime Ether Group

作　　者：刘卫东[1] 兰世林 兰支利[2] 王晓光[1] 

机构地区：[1]湖南化工研究院国家农药创制工程技术研究中心,长沙410007 [2]湖南师范大学化学化工学院,长沙410081

出　　处：《有机化学》2006年第8期1115-1119,共5页Chinese Journal of Organic Chemistry

基　　金：国家十五科技攻关(No.2004BA308A22);湖南省杰出青年科学基金(No.04JJ1009)资助项目.

摘　　要：为了寻找高效、低毒的农药,设计合成了一系列新的含甲硫基和肟醚基的N-甲氧基氨基甲酸酯类化合物5a～5q,其结构经IR,1HNMR,LC/MS和元素分析确认.生物活性测定表明,部分化合物在50mg/L下对稻瘟病菌(Pyriculariaoryzae)、灰霉病菌(Botrytiscinerea)、水稻纹枯病菌(Rhizoctoniasolani)和小麦白粉病菌(Blumeriagriminis)有很好的抑菌活性.In an attempt to find novel compounds with high activity and low toxicity, a series of novel N-methoxylcarbamates containing methylthio and oxime ethers 5a-5q were designed and synthesized according to bioisoster principle. Their structures were confirmed by ^1H NMR, IR, LC/MS spectra and elemental analysis. The prelimilary biological activity tests show that some compounds possess fungicidal activities against Pyricularia oryzae, Botrytis cinerea, Rhizoctonia solani and Blumeria griminis.

关 键 词：甲硫基肟醚 N-甲氧基氨基甲酸酯 合成 杀菌活性 

分 类 号：TQ450.1[化学工程—农药化工]