加替沙星治疗社区获得性呼吸道感染72例  

Clinical Investigation of 72 Cases of Community Acquired Respiratory Tract Infections Treated with Gatifloxacin

作　　者：彭蕻琳 陈小可 罗育新 

机构地区：[1]广东省深圳市第四<福田>人民医院,广东深圳518033

出　　处：《中国药业》2006年第12期47-48,共2页China Pharmaceuticals

摘　　要：目的评价加替沙星治疗社区获得性呼吸道感染(CARTIs)的临床疗效。方法将138例患者随机分为两组,治疗组(72例)予加替沙星400mg,对照组(66例)予左氧氟沙星500mg,均1次/d,静脉滴注或口服,疗程均为7～14d。结果治疗组和对照组临床有效率分别为98.61%和96.97%,平均治愈时间分别为(9.69±1.12)d和(9.51±1.22)d,病原体清除率分别为95.71%和93.65%,不良反应发生率分别为4.17%和3.03%(2/66),均未见光毒性和肝毒性(P均>0.05)。加替沙星对常见7种致病菌的抗菌活性比左氧氟沙星稍好,尤其是肺炎支原体和衣原体。结论加替沙星与左氧氟沙星对CARTIs同样安全有效。Objective To evaluate the treatment effect of gatifloxacin for community acquired respiratory tract infections（CARTIs）. Methods 138 patients with CARTIs were divided randomly into the treatment group （72 cases） and the control group （66 cases）. The treatment group were treated with high dosage of gatifloxacin of 400 mg once daily by oral intake or intravenous drip. The control group were treated with high dosage of levofloxacin of 500 mg once daily by intravenous drip or oral intake. The treatment courses were both 7- 14 d. Results The treatment effect rates of gatifloxacin and levofloxacin were 98.61% and 96.97% respectively. The average cure time was （9.69±1.12） d and （9.51±1.22） d respectively. The bacteriological cure effect was 95.71% and 93.65% respectively （ P 〉 0.05 ）. The minimum inhibition concentration trial showed that gatifloxacin had better activity against 7 kinds of tested pathogenic microorganisms, especially mycoplasma and chlamydia pneumoniae. Conclusion Gatifloxacin and levofloxacin are both safe and effective for CARTIs.

关 键 词：加替沙星 左氧氟沙星 社区获得性呼吸道感染 疗效 

分 类 号：R969.4[医药卫生—药理学] R978.19[医药卫生—药学]