Immunogenicity of formaldehyde and binary ethylenimine inactivated infectious bursal disease virus in broiler chicks  

作　　者：HABIB Mudasser HUSSAIN Iflikhar IRSHAD Hamid YANG Zong-zhao SHUAI Jiang-bing CHEN Ning 

机构地区：[1]Department of Veterinary Microbiology, University of Agriculture, Faisalabad 38040, Pakistan [2]Institute of Preventive Veterinary Medicine, School of Animal Sciences, Zhejiang University, Hangzhou 310029, China

出　　处：《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》2006年第8期660-664,共5页浙江大学学报（英文版）B辑（生物医学与生物技术）

基　　金：Project (No. PSF/Res/P-AU/Bio (246)) supported by Pakistan Sci-ence Foundation (PSF)

摘　　要：Infectious bursal disease virus (IBDV) was inactivated by two different chemicals—formaldehyde and binary ethylenimine (BEI). Formaldehyde was used at 0.1% and 0.2%, while BEI was used at concentrations of 0.001 and 0.002 mol/L. These four vaccines were tested for their efficiency in generating humoral immune response in different groups of broiler chicks. Both BEI-inactivated vaccines gave relatively higher antibody titers and were almost twice as efficient as formaldehyde-inactivated ones.Infectious bursal disease virus （IBDV） was inactivated by two different chemicals-formaldehyde and binary ethylenimine （BEI）. Formaldehyde was used at 0. 1% and 0.2%, while BEI was used at concentrations of 0.001 and 0.002 mol/L. These four vaccines were tested for their efficiency in generating humoral immune response in different groups of broiler chicks. Both BEI-inactivated vaccines gave relatively higher antibody titers and were almost twice as efficient as formaldehyde-inactivated ones.

关 键 词：Infectious bursal disease virus （IBDV） Binary ethylenimine （BEI） FORMALDEHYDE Immune response 

分 类 号：S858.31[农业科学—临床兽医学]