清肺饮合百令胶囊对哮喘大鼠急性期肺组织病理变化的影响  

Influence of Qingfei Decoction combined with Bailing Capsules on pathological changes of lung tissue in rats in acute phase of asthma

作　　者：苏玲[1] 

机构地区：[1]北京中医药大学,北京100029

出　　处：《北京中医药大学学报（中医临床版）》2006年第4期15-17,共3页Journal of Beijing University of Traditional Chinese Medicine

摘　　要：目的探讨清肺饮合百令胶囊治疗哮喘大鼠急性期的作用机制。方法制作SD大鼠哮喘的动物模型,分为正常对照组、模型组、清肺饮合百令胶囊组、清肺饮组、地塞米松组5个组,每组均为10只,观察各组的肺组织病理变化。结果清肺饮合百令胶囊组炎症改善,管壁无明显炎症,淋巴细胞浸润灶明显减少,管腔未见明显狭窄,效果明显优于清肺饮组和地塞米松组。结论百令胶囊能更快地缓解支气管痉挛,减少嗜酸性粒细胞浸润,减轻气道炎症,降低气道的高反应性。Objective To investigate the effective mechanism of Qingfei Decoction combined with Bailing Capsules on rats in acute phase of asthma. Method The animal model of asthma was established with SD rats and then divide them into the group 1 （normal control group）, group 2 （model group）, group 3 （Qingfei Decoction combined with Bailing Capsules group）, group 4 （Qingfei Decoction group） and group 5 （dexamethasone group, each n=10）. The pathological changes in lung tissue were observed in different groups. Result In group 3 the inflammation was relieved. There was no inflammation observed on respiratory tract wall. The lymphocyte infiltration was obviously decreased and stenosis of bronchocavity was not observed. The curative effect in group 3 was better than that in group 4 and group 5. Conclusion Bailing Capsules can relieve more quickly the bronchospasm and inflammation, decrease eosinophils （EOS） infiltration and inhibit the hyperergy of respiratory tract.

关 键 词：补肾 清肺饮 百令胶囊 哮喘急性期 病理 大鼠 

分 类 号：R256.12[医药卫生—中医内科学]