关于一种新疾病“外伤后细菌性致死性肉芽肿”的研究  

Study On A New Entity-Fatal Bacteria Granuloma After Trauma

作　　者：孙东杰[1] 郭照江[2] 齐显龙[1] 高剑[1] 高天文[1] 

机构地区：[1]第四军医大学西京医院皮肤科全军皮肤性病中心,陕西西安710032 [2]第四军医大学社科部,陕西西安710032

出　　处：《医学与哲学（B）》2006年第7期37-38,共2页Medicine & Philosophy(B)

摘　　要：外伤后细菌性致死性肉芽肿(FBGT)是一种新发现的疾病,该病的研究没有成熟的思路可供借鉴。我们从该病的临床表型出发,通过综合分析,推测该病属于细菌感染性疾病,并成功分离、鉴定了该病的病原菌;为研究该病的发病机制,依据该病的临床特点,确认患者对病原菌易感是该病发生的主要因素;在充分借鉴他人的研究成果的基础上,我们提出了IFN-γ相关分子基因多态性是FBGT发病的主要机制的假说,最终通过实验证实了该假说。Fatal bacteria granuloma after trauma is a new entity. The principle and procedure of the study on the new entity is not available. By thoroughly investigating the patients＇ phenotype, the new entity was thought to be a infectious one, and the infectious agent was successfully isolated and identified. By extensively analyzing the epidemiological patterns,a hypothesis was proposed that IFN- γ associated molecules gene polymorphism is the main pathogenesis of hosts＇ susceptibility to the infectious agent. Finally the experiment verified the hypothesis.

关 键 词：外伤后细菌性致死性肉芽肿 研究 发病机制 

分 类 号：R758.6[医药卫生—皮肤病学与性病学]