煤工尘肺患者TGF-β1基因与环境暴露因素的交互作用  

Interaction of TGF-β1 alleles and environmental factors in coal worker pneumoconiosis

作　　者：毋小玉[1] 姚武[2] 李丽[3] 郝长付[2] 王娜[2] 

机构地区：[1]河南省人民医院检验科,郑州450003 [2]郑州大学公共卫生学院劳动卫生学与职业病学教研室,郑州450052 [3]郑州大学第一附属医院儿科,郑州450052

出　　处：《郑州大学学报（医学版）》2006年第4期681-682,共2页Journal of Zhengzhou University(Medical Sciences)

基　　金：郑州大学青年骨干教师基金资助项目

摘　　要：目的:探讨基因多态性与环境暴露因素交互作用对煤工尘肺发生、发展的影响。方法:采用单纯病例研究方法,对110例汉族煤工尘肺患者进行问卷调查,采集外周静脉血,提取DNA,应用PCRRFLP技术检测其TGFβ1基因509位点多态性,对煤工尘肺患者TGFβ1基因509位点基因型与环境暴露等因素交互作用进行分析。结果:煤工尘肺患者TGFβ1基因509位点C/T和T/T基因型在吸烟组中的比例高于不吸烟组,差异有统计学意义(ORadj=2.357,95%CI1.254～4.430,P<0.05);在接尘工龄≥20a组中的比例高于接尘工龄<20a组,差异有统计学意义(ORadj=3.022,95%CI1.645～5.553,P<0.05)。结论:TGFβ1基因509位点多态性与吸烟、接尘工龄存在交互作用,增加了煤尘接触者发生煤工尘肺的危险性。Aim ： To study the interaction of TGF-181-509 alleles and environmental factors in coal worker pneumoconiosis （CWP）. Methods： A total of 110 CWPs were investigated. The TGF-β1-509 alleles were examined by PCR-RFLP. Use case-only study to approach the interaction of CWP TGF-β1-509 alleles and environmental factors. Results, The frequence of C/T,T/T in smoking group was higher than that in non-smoking group（ OR adj = 2. 357, 95% CI 1. 254 4. 430,P 〈 0. 05 ）. The frequence of C/T, T/T in exposure years ≥ 20 years group was higher than that in exposure years 〈 20 years （ OR adj = 3. 022, 95% CI 1. 645 - 5. 553, P 〈 0. 05 ）. Conclusion： There was interaction between TGF-β1-509 alleles and smoking, exposure years,which increases the risk possibility of CWP.

关 键 词：煤工尘肺 环境因素 TGF—β1 交互作用 单纯病例研究 

分 类 号：R135.2[医药卫生—劳动卫生]