肝移植后移植物抗宿主病研究进展  

Research progress of graft-versus-host disease after liver transplan-tation

作　　者：汤晓锋[1] 郑树森[1] 梁廷波[1] 

机构地区：[1]浙江大学医学院附属第一医院,浙江杭州310003

出　　处：《浙江大学学报（医学版）》2006年第4期453-457,462,共6页Journal of Zhejiang University(Medical Sciences)

基　　金：国家"973"重点基础研究发展规划基金资助项目(2003CB5155001)

摘　　要：肝移植后移植物抗宿主病(graft-versus-host d isease,GVHD)较为少见,其发病机制不甚清楚,缺乏针对性治疗手段,预后极差。HLA配合率高、受体年龄大、免疫力低下是发生GVHD的高危因素;下调免疫抑制剂,联合大剂量激素或应用抗IL-2受体单克隆抗体,可能是治疗GVHD较为合理的方案。Graft-versus-host disease （GVHD） is an uncommon but fatal complication of orthotopic liver transplantation （OLT）. The pathogenesis and mechanism of GVHD after OLT remains unclear and the treatment is therefore largely empirical. The prevention of GVHD including avoidance of closely matched human leukocyte antigen donors and old-age recipients is of particular importance because effective treatment is lacking. To reduce immunosuppressants combined with high dose of methylprednisolone and reasonable regime.

关 键 词：肝移植 移植物抗宿主病 HLA配型 

分 类 号：R657.3[医药卫生—外科学] R392.32[医药卫生—临床医学]