Effects of nine antihypertensive drugs on blood pressure variability in sinoaortic-denervated rats  

作　　者：Jin Wang Fu-ming SHEN Min-wei WANG Ding-feng SU 

机构地区：[1]Department of Pharmacology, Second Military Medical University. Shanghai 200433 [2]Department of Pharmacology, Shenyang Pharmaceutical University Shenyang 110016, China

出　　处：《Acta Pharmacologica Sinica》2006年第8期1013-1017,共5页中国药理学报（英文版）

基　　金：Project supported by grants from the National Natural Science Foundation of China(№ 30330650);the Science and Technology Development Foundation of Shanghai(№ 03JC14001,04JC14001).

摘　　要：Aim： The present work was designed to investigate the effects of nine commonly used antihypertensive drugs on blood pressure （BP） and blood pressure variability （BPV） in conscious sinoaortic-denervated （SAD） rats, Methods： Seventy-two SAD rats were randomly divided into nine groups. They were respectively given nifedipine 3 mg/kg, nitrendipine 5 mg/kg, amlodipine 1 mg/kg, clonidine 10 μg/kg, prazosin 0.5 mg/kg, atenolol 20 mg/kg, telmisartan 20 mg/kg, hydrochlorothiazide 40 mg/kg or captopril 50 mg/kg. The drugs were given via a catheter previously implanted into the stomach. BP was recorded for 5 h from 1 h before drug administration to 4 h after drug administration in conscious, freely moving rats. Results： It was found that all these nine drugs significantly decreased BP in SAD rats. Six of these drugs （nifedipine, nitrendipine, amlodipine, clonidine, prazosin and atenolol） significantly decreased BPV in SAD rats, but the remaining three drugs did not. Clonidine and atenolol increased the heart period and the others did not. No drugs affected the heart period variability. Conclusion： Among nine antihy- pertensive drugs from different classes, calcium antagonists and sympathetic inhibitors decreased BPV in SAD rats.Aim： The present work was designed to investigate the effects of nine commonly used antihypertensive drugs on blood pressure （BP） and blood pressure variability （BPV） in conscious sinoaortic-denervated （SAD） rats, Methods： Seventy-two SAD rats were randomly divided into nine groups. They were respectively given nifedipine 3 mg/kg, nitrendipine 5 mg/kg, amlodipine 1 mg/kg, clonidine 10 μg/kg, prazosin 0.5 mg/kg, atenolol 20 mg/kg, telmisartan 20 mg/kg, hydrochlorothiazide 40 mg/kg or captopril 50 mg/kg. The drugs were given via a catheter previously implanted into the stomach. BP was recorded for 5 h from 1 h before drug administration to 4 h after drug administration in conscious, freely moving rats. Results： It was found that all these nine drugs significantly decreased BP in SAD rats. Six of these drugs （nifedipine, nitrendipine, amlodipine, clonidine, prazosin and atenolol） significantly decreased BPV in SAD rats, but the remaining three drugs did not. Clonidine and atenolol increased the heart period and the others did not. No drugs affected the heart period variability. Conclusion： Among nine antihy- pertensive drugs from different classes, calcium antagonists and sympathetic inhibitors decreased BPV in SAD rats.

关 键 词：antihypertensive drugs blood pressure bloodpressure variability sinoaortic denervation 

分 类 号：R544.1[医药卫生—心血管疾病]