A771726的抗银屑病作用及对免疫功能的影响  

Effect of A771726 on psoriasis animal model and immune function in mice

作　　者：张茜[1] 彭磊[1] 石静波[1] 刘骅[1] 李荣[1] 金涌[1] 

机构地区：[1]安徽医科大学药学院,合肥230032

出　　处：《安徽医科大学学报》2006年第4期417-420,共4页Acta Universitatis Medicinalis Anhui

基　　金：安徽省教育厅自然科学基金项目(编号:2004kj196);安徽医科大学博士基金项目(2005年)

摘　　要：目的探讨A771726的抗银屑病作用及部分免疫功能。方法采用鼠尾鳞片表皮模型及小鼠阴道上皮模型,观察A771726对表皮细胞分化及上皮细胞有丝分裂的影响。并通过检测ConA诱导T淋巴细胞增殖及LPS诱导腹腔巨噬细胞产生IL-1,观察A771726对免疫功能的影响。结果A771726能促进小鼠尾部鳞片表皮颗粒层形成,抑制小鼠阴道上皮细胞的有丝分裂,对ConA诱导T淋巴细胞增殖反应及LPS诱导IL-1的产生均有抑制作用。结论A771726可能通过抑制表皮细胞增殖及促其分化,并通过一定的抗炎及免疫调节而发挥抗银屑病作用。Objective To study the effects of A771726 on psoriasis animal model and immune function in mice. Methods The mouse tail scaled epidermis and the vaginal epithelial in estrus cycle were used to assess the antipsoriasis effect of A771726. ConA -induced proliferation of T lymphocyte, LPS-induced production of IL-1 by the peritoneal macrophages were determined. Results A771726 significantly inhibited the mitosis of vaginal epithelial cells in mice treated with estrogen and promoted the formation of granular layer in the tail scale epidermis. And A771726 inhibited the proliferation of T lymphocyte, the production and proliferation of IL-1. Conclusion The anti-psoriatic effect of A771726 may be related to promoting the formation of granular cells and inhibiting hyperplasia of epidermal cells and possessing anti-inflammatory and immunomodulatory activity.

关 键 词：银屑病/药物疗法 免疫/药物作用 

分 类 号：R758.63[医药卫生—皮肤病学与性病学] R971.1[医药卫生—临床医学]