Er∶YAG激光制洞对牙髓的生物学效应  

Analysis of pulpal response to cavity preparation by Er:YAG laser in rabbits

作　　者：潘蕾[1] 梅陵宣[1] 陈乔尔[1] 

机构地区：[1]安徽医科大学口腔医学院,合肥230032

出　　处：《安徽医科大学学报》2006年第4期469-471,共3页Acta Universitatis Medicinalis Anhui

摘　　要：目的观察Er∶YAG激光制洞对兔牙髓组织的影响。方法分别用Er∶YAG激光和普通牙钻于兔前牙唇面制备V类洞,常规窝洞垫底充填。术后即刻和72h处死动物并分离实验牙,HE染色观察兔牙髓的形态学改变。术后72h,免疫组化S-P法检测转化生长因子β1(TGF-β1)在牙髓中的表达。结果术后即刻和72h Er∶YAG激光组与普通牙钻组均可见牙髓轻度炎性反应;术后72h激光组及普通牙钻组均可见成牙本质细胞内及其下方牙髓细胞内TGFβ1的表达,两组比较差异有显著性(P<0.05),激光组牙髓组织内TGF-β1的中强阳性表达率(90%)高于普通牙钻组(30%)。结论与普通牙钻组比较,Er∶YAG激光制洞对牙髓组织未见有明显损伤;Er∶YAG激光辐射可能具有促进牙髓组织修复的潜能。Objective To observe the pulpal response to cavity preparation using Er ： YAG laser in rabbit incisors. Methods Following Er ： YAG laser and the conventional bur excavation, the cavities in dentine were closed temporarily and the teeth were extracted immdiatelly and after 72 hours post-operation. The pulp were examined histologically and immunohistolobically for TGF-β1. Results There was no marked difference in the manner in which pulp tissue responded to cavity preparation with either laser or a convential drill. Immunohistochemical staining of TGF-β1 was more significant in the laser group. Conclusion Er ： YAG laser causes no serious pulpal for cavity preparation and may hold the potienal for dental tissue repair.

关 键 词：激光/治疗应用 牙髓疾病 转化生长因子β/分析 

分 类 号：R454.2[医药卫生—治疗学] R781.3[医药卫生—临床医学]