聚乳酸管对大鼠坐骨神经吻合口及其功能恢复的影响  

The influence of polylactic-acid tube on the anastomotic stoma of rat sciatic nerve and its functional recovery

作　　者：侯建伟[1] 张铁良[1] 范正伟 徐小红[1] 铁钰 朱宏伟 

机构地区：[1]河南省人民医院,河南省伊川县人民医院,河南省滑县第二人民医院,河南省西华县公疗医院

出　　处：《中医正骨》1996年第5期3-4,共2页The Journal of Traditional Chinese Orthopedics and Traumatology

基　　金：河南省科委科研资金

摘　　要：用ＳＤ大鼠坐骨神经研究聚乳酸管和硅胶管对神经离断伤吻合口的影响。单侧坐骨神经完全离断后行单纯端端吻合，吻合口处套以聚乳酸管和硅酸管，于术后８周取出标本，进行肉眼、光镜、电生理和双侧腓肠肌湿重测定。结果表明，聚乳酸管可以有效地预防神经吻合口的粘连和疤痕组织对其产生压迫和固定，提高周围神经损伤后的功能恢复率，为神经再生提供一个不受外界干扰的，有利于其生长的＂微环境＂。The influence of polylactic-acid and silicone tubes on the anastomotic stoma of ampulated nerves is studied with SD rat sciatic nerves in the paper. The simple end-to-end anastomosis was performed on the unilateral sciatic nerve completely severed ,and the anastomosed site was slipped into polylactic-acid and silicone tubes. Eight weeks after operation ,the sample resected was observed by naked eye ,optical microscopy and electrophysiology and the wet weight of the gastrocnemius muscles on both sides was measured. The results suggested that the polylactic-acid tube could effectively prevent the adhesion,compression and fixation of the nervous anastomotic stoma from the scar tissues, improve the functional recovery rate of the injured peripheral nerves,and provide the nerve regeneration with a good 'microenvironment' , not being disturbed by the outer sphere but benefiting the nerve growth.

关 键 词：坐骨神经 外科手术 断端吻合术 聚乳酸管 

分 类 号：R651.3[医药卫生—外科学]