川芎嗪局部静脉给药对肢体缺血-再灌注损伤的保护作用  

Protection of local intravenous administration of ligustrazine against ischemic reperfusion of limbs

作　　者：方剑[1] 李涛[1] 方晓萍[1] 刘克明[1] 宋晓辉[1] 

机构地区：[1]广东省中医院珠海医院麻醉科,519015

出　　处：《临床麻醉学杂志》2006年第7期508-510,共3页Journal of Clinical Anesthesiology

基　　金：珠海市卫生局课题资助项目(项目编号:2005063)

摘　　要：目的研究局部患肢静滴川芎嗪对肢体缺血-再灌注损伤的保护作用，对比外周静脉用药是否有差异。方法59例择期手术患者，随机分19例局部静脉给药组（A组），18例外周静脉给药组（B组）和22例空白对照组（C组）。于止血带充气前（T0）、止血带放气后0～1min（T1）、15min（T2）、30min（T3）各时点测量外周及患肢静脉血浆的脂质过氧化物丙二醛（MDA）含量。结果与B组比较，T3时A组MDA值低于B组（P〈0．05）；三组比较，T3时患肢静脉血样中的MDA差异有显著意义（P〈0．05）；T3时C组中患肢静脉MDA值高于外周静脉MDA值（P〈 0．05）。结论局部静脉注射川芎嗪对肢体缺血-再灌注损伤具有一定的保护作用，且效果比外周静脉用药好。肢体缺血-再灌注损伤研究中，不宜简单以外周静脉血标本替代局部静脉血标本。Objective To study the protection effect of local intravenous administration of ligustrazine against ischemic reperfusion of the limbs. Methods Fifty-nine patients undergoing lower limb operations were studied. The patients were randomly divided into 3 groups： 19 cases in group A （local intravenous administration）, 18 in group B （peripheral intravenous administration） and 22 in group C （control）. Blood samples were obtained before fastening tourniquet, at 1 and 15 and 30 min after release of tourniquet （reperfusion）. MDA was measured and compared. Results MDA after 30 min of reperfusion in group A was significantly less than that in group B （P〈0.05）. At 30 min of reperfusion MDA significant differences are seen among group A, B and C （P〈0.05）. At 30 rain after reperfusion in group C, MDA in tourniquet site was significantly higher than that in peripheral vein （P〈0.05）. Conclusion Local intravenous administration of ligustrazine has protective effect against isehemie reperfusion of the limbs, which is more efficacious than peripheral intravenous administration. The level of peripheral venous samples is different from that of local venous samples in limbic local ischemia reperfusion. Therefore, in experiment of ischemic reperfusion in limb, it is not recommended to take a peripheral blood sample.

关 键 词：缺血-再灌注 川芎嗪 止血带 

分 类 号：R269[医药卫生—中西医结合]