别嘌呤醇所致药疹21例临床分析  

Clinical analysis of 21 cases of drug eruption caused by allopurinol

作　　者：吴兴文[1] 支和平[2] 

机构地区：[1]上海市闸北区中心医院药剂科,上海200070 [2]上海市闸北区中心医院皮肤科,上海200070

出　　处：《世界感染杂志》2006年第4期354-355,共2页World Journal of Infection

摘　　要：目的 了解别嘌呤醇的药物不良反应。方法 对本院1993年1月至2001年12月间收治的别嘌呤醇所致药疹21例进行临床分析。结果 21例药疹病人中，诊断重症多形红斑型5例，剥脱性皮炎4例，多形红斑型4例，大疱表皮坏死松解型3例，麻疹样型3例，紫癜型2例。病人年龄39-81（58．3± 18．7）岁。结论 年龄〉50岁的病人应用别嘌呤醇应谨慎。Objective To comprehend the side effects of allopurinol. Methods 21 cases of drug eruption caused by allopurinol from Jan 1993 to Dec 2001 in our hospital were retrospectively analyzed. Results Among total 21 cases, 5 cases of Stevens-Johnson disease, 4 cases of dermatitis exfoliativa, 4 cases of erythema polymorphe, 3 cases of bulla epidermal necrolysis; epidermsl necrolysis, 3 cases of measles type, and 2 cases of peliosis type were encountered. Average age of patients was 39-81 （58.3±18.7） y. Conclusion Caution should be payed while elder patients （〉50y） received allopurinol.

关 键 词：药疹 别嘌呤醇 

分 类 号：R969[医药卫生—药理学]