可溶性CD40配体与急性冠状动脉综合征的关系  

Relation between soluble CD40 ligand and the acute coronary syndromes

作　　者：刘建萍[1] 葛郁芝[2] 张卫 曾黎峰[1] 汪玉如[1] 

机构地区：[1]江西省人民医院,江西省南昌市330006 [2]江西省心血管病研究所 [3]江西南昌大学第三附属医院

出　　处：《中国心血管病研究》2006年第8期565-567,共3页Chinese Journal of Cardiovascular Research

基　　金：江西省卫生厅课题(20041008)

摘　　要：目的探讨急性冠脉综合征(ACS)患者血清可溶性CD40L水平变化的临床意义。方法正常对照组22名,将患者分为稳定型心绞痛(SA)组20例、不稳定型心绞痛(UA)组22例和急性心肌梗死(AMI)组15例。其中20例(UA组15例、AMI组5例)行经皮冠状动脉介入术(PCI)。所有受试者均采用双抗夹心酶联免疫测定法(ELISA)对sCD40L水平进行检测,同时观察冠脉造影和PCI术前和术后30dsCD40L的水平变化。结果①UA组及AMI组血清sCD40L水平明显较对照组高(P<0.01)。②UA组与SA组相比差异有统计学意义(P<0.05),AMI组明显较SA组高(P<0.01)。③SA组与对照组相比差异有统计学意义(P<0.01)。④AMI组患者血清sCD40L水平与UA组差异有统计学意义(P<0.01)。⑤PCI后30d血清sCD40L明显低于PCI前(P<0.01)。结论血清可溶性sCD40L的升高在ACS发生和发展中起重要作用,是反应斑块不稳定性的指标之一。Objective This research aims to expose the clinical implication of soluble CD40 ligand. Methods 57 patients were divided into three groups including 20 stable angina （SA）,22 unstable angina （UA）and 15 acute myocardial infarction （AMI） and seven of them underwent PCI.There were 22 as control group. Serum levels of sCD40L were determined by enzyme linked immununosorbent assay（ELISA ）. Meanwhile, the levels of sCD40L were compared with morphology of complex stenoses and the levels of sCD40L before and after PCI 30 days. Results （ 1 ）The levels of serum sCD40L were significantly higher in the UA and AMI group than in the control group （ 6.43±2.61, 9.69±3.17 vs 2.64±0.59,P〈0.01）.（2）The levels of sCD40L were higher in the UA group than in the SA group（6.43±2.61 vs 4.72±1.51 ,P〈0.05 ）. The levels of sCD40L were significantly higher in the AMI group than in the SA group （9.69±3.17 vs 4.72±1.51,P〈0.05）. （3）The levels of sCD40L is significantly higher in the SA group than in the control group （4.72±1.51 vs 2.64±0.59, P〈0.01）. （4）The levels of sCD40L were significantly higher in the AMI group than in the UA group （9.69±3.17 vs 6.43±2.61, P〈0.01）. （5）The levels of sCD40L is significantly lower in the after PCI 30 days group than in the before PCI group （t=13.97,P〈0.01）. Conclusion The enhanced level of serum soluble CD40L may play an important role in acute coronary syndromes.h is one of the index of reflecting instability of atheoscleotic plaques.

关 键 词：CD40配体 急性冠脉综合征 动脉硬化 心绞痛 

分 类 号：R541.4[医药卫生—心血管疾病]