安息香及其类似物在苯基甘氨酸型手性固定相上的拆分  

Resolution of benzoin and its analogues with (R)-phenylglycine based chiral stationary phase

作　　者：姚碧霞[1] 尤秀丽[1] 叶农钦[1] 熊雪珠[1] 翁文[1] 

机构地区：[1]漳州师范学院化学与环境科学系,福建漳州363000

出　　处：《应用化工》2006年第7期554-555,558,共3页Applied Chemical Industry

基　　金：福建省自然科学基金项目(C0540024);福建省教育厅项目(JA05301)

摘　　要：正相模式下研究了安息香、氢化安息香及α-苯乙醇在苯基甘氨酸型手性固定相Ch irex 3001上的拆分,探讨了流动相组成及柱温对手性拆分效果的影响。当流动相为正己烷∶1,2-二氯乙烷∶乙醇(体积比)=83.5∶15∶1.5,流速为1.0 mL/m in,柱温为25℃时,三者的分离因子分别为1.04、1.11和1.02。此方法可用于氢化安息香等光学纯度的测定。Resolution of benzoin, hydrobenzoin and α-phenethyl alcohol with （R）-phenylglycine based chiral stationary phase（ Chirex 3001 ） in the normal-phase conditions were studied. The effects of the mobile phase composition and the column temperature on the chiral resolution were investigated. When nhexane： 1,2-dichloroethane： ethanol（ volume ratio, 83.5： 15：1.5 ）was used as mobile phase at a flow rate of 1.0 mL/min, the column temperature 25℃, the separation factors were 1.04,1.11 and 1.02 respectively for these three compounds. The method can be used to determine optical purity of hydrobenzoin.

关 键 词：手性拆分 苯基甘氨酸 安息香 氢化安息香 苯乙醇 

分 类 号：O657.7[理学—分析化学]