高效液相色谱法纤维素类手性固定相分离手性化合物  

Chiral separation of chiral compounds on cellulose chiral column by HPLC

作　　者：刘峻[1] 韩小茜[1] 李军[1] 魏燕[1] 

机构地区：[1]兰州交通大学化学与生物工程学院,甘肃兰州730070

出　　处：《应用化工》2006年第7期559-560,共2页Applied Chemical Industry

摘　　要：在手性柱OJ-H上直接分离了三种手性化合物,并初步探讨了手性化合物在不同流动相的组分———醇的种类及结构对手性拆分的影响,结果发现,溶质与固定相分子之间的氢键作用、π-π作用对溶质的手性分离有一定的影响。另外,不同直链醇作为流动相也影响着手性化合物的保留与分离。The chiral separations of three chiral compounds were directly performed on polysaccharidebased chiral OJ-H. The influence of the mobile phase modifier and the structures and types of alcohol on the chiral separation were investigated. Results indicated that the chiral separation depends strongly upon hydrogen bonding and the π-π interaction between the analyte and CSP molecules. Moreover, the carbon number of the alcohol in the mobile phase also affects the retention and resolution of the chiral compound.

关 键 词：手性固定相 手性化合物 手性分离 

分 类 号：O657.72[理学—分析化学]