失血大鼠肝、脑组织糖皮质激素受体的变化及其意义  

Change of glucocorticoid receptor in hepatic and cerebral tissues and its role in hemorrhagic rats/

作　　者：石汉平[1,2,3] 李建珍 秦路平 缪明永[1,2,3] 杨林[1,2,3] 宋春桥 谭金兴[1,2,3] 徐仁宝 

机构地区：[1]广州市第一军医大学南方医院普外科 [2]广州武警总队医院急诊科 [3]第二军医大学

出　　处：《中国危重病急救医学》1996年第10期577-578,共2页Chinese Critical Care Medicine

摘　　要：探讨动物失血后肝、脑组织糖皮质激素受体（ＧＲ）的变化及其意义。成年雄性ＳＤ大鼠，麻醉后经颈动脉插管放血０～４０％，或肌注不同剂量的Ｒｕ４８６以阻断组织的ＧＲ０，５０％和８０％。结果：大鼠失血０～４０％后３小时，肝、脑组织胞液ＧＲ量随失血量增加而进行性下降；大鼠失血３０％后０～３小时，肝、脑组织ＧＲ含量随失血持续时间延长而进行性减少；组织ＧＲ与失血量、失血持续时间呈显著的负相关。预先阻断大鼠ＧＲ０、５０％和８０％后再放血１０％，结果ＧＲ阻断率越大，则大鼠颈动脉压越低，时间存活率越小。提示：失血可引起组织ＧＲ减少，失血量越大、失血持续时间越长，ＧＲ减少越明显；Change of glucocorticoid receptor(GR) and its role after hemorrhage in adult SD rats were studied.carotid catheterization was performed and bloodletting(040%) done after anesthesia,or different doses of Ru 486 were injected intramuscularly to block tissue GR(0,50% and 80% respectively).Three hr after blood loss (040%) hepatic and cerebral cytoplasmic GR reduced progressively with increasing blood loss.03hr after blood loss(30%),GR reduced progressively with the prolongaiton of blood loss.There was a significantly negative correlation berween tissue GR and the amount and duration of blood loss.After blockade of the GR(0,50% and 80%),bloodletting(10%) was done.It was found that the higher the blocked GR rate the lower the carodid pressure,and the lower the time survival rate.The result showed that hemorrhage could cause significant decrease of GR,and the degree of decreased GR correlated with the seriousness of hemorrhage.GR may be used as an important mark revealing the seriousness of hemorrhage,and predicting the prognosis of hemorrhage.

关 键 词：失血 受体 糖皮质激素 大鼠 

分 类 号：R605.972[医药卫生—急诊医学]