2型糖尿病患者血清抵抗素与尿白蛋白排泄率的关系  

Relationship between resistin and UAER in patients with type 2 diabetes mellitus

作　　者：孙小东[1] 赵晓娟[1] 于学满[1] 

机构地区：[1]中国医科大学附属一院内分泌科,辽宁沈阳110001

出　　处：《中国现代医学杂志》2006年第14期2154-2156,共3页China Journal of Modern Medicine

摘　　要：目的检测不同尿白蛋白排泄率(UAER)的2型糖尿病患者血清抵抗素(RESISTIN)水平,并探讨尿白蛋白排泄率与抵抗素之间的关系。方法酶联免疫检测法(ELISA)测定60例研究对象空腹血清抵抗素水平。其中2型糖尿病伴微量白蛋白尿组20例;2型糖尿病UAER正常组20例,健康对照组20例。结果2型糖尿病伴微量白蛋白尿组的血清抵抗素浓度高于2型糖尿病UAER正常组(P<0.05);且2型糖尿病UAER正常者组的抵抗素水平又高于健康对照组(P<0.05);其值分别为1.80(1.55～2.45);1.57(1.29～1.87);1.29(1.07～1.47)。结论2型糖尿病及其微量白蛋白尿的形成可能与抵抗素相关。[Objective] To investigate the level of serum resistin in the subject suffering from Type2 diabetes with different UAER and control groups. Then we try to find out the correlation among them. [Method] 40 patients with different quantity of Albuminufia（20 of Type2 diabetes were with miero-UAER, 20 of Type2 diabetes were with normal -UAER） were selected as study groups, 20 healthy persons were selected as control group. The levels of resistin were measured after an overnight fasting by competitive ELISA. [Result] The fasting serum level of resistin in Type2 diabetes with micm-UAER were higher than that of Type2 diabetes with normal-UAER （P 〈0.05） and control group （P 〈0.05）; the figure were 1.80 （1.55～2.45）; 1.57 （1.29～1.87）; 1.29 （1.07～1.47） repectively. [Conclusion] Resistin may play a role in the form of Albuminufia of Type2 diabetes.

关 键 词：抵抗素 2型糖尿病 尿白蛋白排泄率 

分 类 号：R587.1[医药卫生—内分泌]