含α-氨基酸的新型有机锗化合物的合成与生物活性研究  

Syntheses of Novel Organogermanium Compounds Containing α-Amino Acid and Studies on the Antitumor Activity

作　　者：陈建新[1] 陈莉[1] 翟玉平[2] 史寅 孙丽娟[1] 

机构地区：[1]南开大学元素有机化学重点实验室 [2]南开大学化学学院化学系,天津300071

出　　处：《高等学校化学学报》2006年第8期1476-1479,共4页Chemical Journal of Chinese Universities

摘　　要：设计合成了两个系列20个含α-氨基酸的新型有机锗化合物,对化合物进行了波谱表征,用X射线衍射测定了化合物Ph3GeCH(Ph)CH2CONHCH(CH2COOC2H5)COOC2H5的晶体结构.抗肿瘤实验结果表明,这两个系列的化合物有一定的抗KB,HCT-8和Bel-7402活性.In order to search new organogermanium antitumor drugs with an activity and low toxicity, 20 new organogermanium compounds were designed and synthesized by attaching α-amino acid to organogermanium moieties. Their structures were confirmed by IR, 1H NMR and elemental analysis. The crystal structure of Ph3GeCH（Ph） CH2CONHCH （ CH2COOC2H5 ） COOC2H5 were determined by X-ray diffraction. Three human neoplastic cell lines（KB, HCT-8 and Bel-7402） were used to screen these compounds. The results indicate that some compounds at 5 μmol/L show a weak in vitro antitumor activity.

关 键 词：有机锗化合物 Α-氨基酸 晶体结构 抗肿瘤活性 

分 类 号：O621.3[理学—有机化学]