酶促缩聚和原子转移自由基聚合法合成AB型两亲性嵌段共聚物  

Synthesis of Amphiphilic Diblock Copolymer Poly(10-hydroxydecanoic acid)/poly(glycidyl methacrylate) by Combining Enzymatic Condensation Polymerization and ATRP

作　　者：李冬霜[1] 沙柯[1] 李亚鹏[1] 刘啸天[1] 艾鹏[1] 王薇[1] 陈亮[2] 王静媛[1] 

机构地区：[1]吉林大学化学学院麦克德尔米德实验室,长春130012 [2]吉林大学第一医院,长春130023

出　　处：《高等学校化学学报》2006年第8期1575-1578,共4页Chemical Journal of Chinese Universities

基　　金：国家自然科学基金(批准号:20574028)资助

摘　　要：Novozym e-435催化10-羟基癸酸进行自缩聚反应得到线性聚酯,端基分别是羟基(—OH)和羧基(—COOH),在三乙胺催化下,分别用α-溴代丙酰溴和三甲基氯硅烷(TMSCL)进行端基官能化生成一个单官能度的大分子引发剂,在CuC l/2,2′-联吡啶(bpy)催化体系中,引发甲基丙烯酸环氧丙酯(GMA)的原子转移自由基反应(ATRP),得到聚(10-羟基癸酸酯)/聚甲基丙烯酸环氧丙酯(PHDA-b-PGMA)AB型两亲性嵌段共聚物,其结构及分子量(分布)通过核磁共振和凝胶渗透色谱(GPC)确证.此AB型两亲性嵌段共聚物在水溶液中能自组装形成纳米粒子,用原子力显微镜(AFM)观察粒子的形状和大小.The diblock copolymers poly （10-hydroxydecanoic acid ）-block poly （glycidyl methacrylate ） （PHDA-b-PGMA） were synthesized by combining enzymatic condensation polymerization of 10-hydroxydecanoic acid （HDA） and atom transfer radical polymerization （ATRP） of glycidyl methacrylate （GMA）. PHDA was firstly obtained via enzymatic condensation polymerization catalyzed by Novozyme-435. Subsequently one end of PHDA chains was modified by reaction with c^-bromopropionyl bromide and the other was protected by chlorotrimethylsilane （TMSCL）, respectively, the resulting monofunctional macroinitiator was used in the ATRP of GMA using CuCI/2,2＇-bipyridine（bpy） as the catalyst system to afford the diblock copolymers including biodegradable PHDA blocks and well-defined PGMA blocks. Polymer nanospheres were prepared by the self-assembly behaviors of the amphiphilic diblock copolymers PHDA-b-PGMA in aqueous solvent.

关 键 词：酶促缩聚 原子转移自由基聚合 嵌段共聚物 自组装 

分 类 号：O631[理学—高分子化学]