O-羧甲基壳聚糖的制备及波谱分析  

Synthesize of O-Carboxymethyl Chitosan

作　　者：张贵芹 赵丽瑞[2] 刘满英[2] 

机构地区：[1]山东省化学研究院,济南市250014 [2]河北医科大学基础医学院,石家庄市050017

出　　处：《光谱实验室》2006年第4期658-661,共4页Chinese Journal of Spectroscopy Laboratory

摘　　要：壳聚糖与氯乙酸在氢氧化钾-异丙醇介质中作用,制备O-羧甲基壳聚糖。研究了反应温度、壳聚糖与氯乙酸质量比、氢氧化钾与氯乙酸质量比对反应产物结构的影响。壳聚糖与氯乙酸、氢氧化钾与氯乙酸的质量比分别在2∶1及2.3∶1时,室温下反应5h可得到较高取代度的O-羧甲基壳聚糖。采用红外光谱扫描法及X光电子能谱分析法对产物结构进行了表征。O-eaboxymethyl chitosan was prepared by chitosan and monocholoroacetic in KOH- isopropanol. The factors which influence the substitute position of carboxymethl in preparation of carboxymethyl chitosan were studied. Thus when the value of the WKKOH：WCICH2COOH：WCTS was 2. 3 ： 2 ： 1, the temperature was 20 C, the substitute reaction occurred at -OH. The chemical characteristics of the production were evaluated by Fourier-transformed infrared （FTIR） and X-ray photoelectron spectroscopy （XPS）.

关 键 词：羧甲基壳聚糖 壳聚糖衍生物 X射线光电子能谱分析 

分 类 号：O657.33[理学—分析化学]