左旋千金藤立定对大鼠阻力动脉的松弛作用  

RELAXING EFFECTS OF l STEPHOLIDINE ON RAT RESISTANCE ARTERIES

作　　者：石磊 王永信 薛爱琴 

机构地区：[1]徐州市医学科学研究所阻力动脉研究室

出　　处：《药学学报》1996年第7期492-495,共4页Acta Pharmaceutica Sinica

基　　金：江苏省留学回国基金

摘　　要：应用离体阻力动脉技术，研究了左旋千金藤立定（ｌｓｔｅｐｈｏｌｉｄｉｎｅ，ｌＳＰＤ）对离体阻力动脉的松弛作用。ｌＳＰＤ对ＫＣｌ（１２５ｍｍｏｌ·Ｌ－１）引起的心、肾、脑、肠系膜的阻力动脉收缩均有松弛作用，其中以脑阻力动脉的松弛作用为最弱，－ＬｏｇＥＣ５０值为４．２５±０．２２；对肠系膜阻力动脉的松弛作用为最强，－ＬｏｇＥＣ５０值为４．７６±０．１５。上述结果提示，ｌＳＰＤ直接松弛内脏阻力动脉、降低外周阻力。Bolus injection(iv) of l stepholidine( l SPD, 3 mg·kg -1 ) caused hypotension in anaesthetized rats. The blood pressure reduction was sustained for 46.3±14.1 min. In in vitro experiments, l SPD induced a concentration dependent relaxation of rat mesenteric, cerebral , renal and coronary resistance arteries preconstricted with 125 mmol·L -1 KCl. l SPD was least potent with cerebral resistance arteries with the -Log EC 50 value being 4.25±0.22. The relaxation of l SPD on mesenteric resistance arteries was the most potent with the -Log EC 50 value being 4.76±0.15. The larger influence of l SPD (100 μmol·L -1 ) on the contraction induced by KCl in mesenteric than in cerebral arteries was in line with the above results . It is indicated that l SPD has a direct relaxation on visceral resistance arteries with some degree of selectivity and the relaxation would decrease total peripheral resistance and thus constitute an important cause of its hypotensive action.

关 键 词：左旋千金藤立定 降压作用 阻力动脉 降压药 

分 类 号：R972.4[医药卫生—药品]