反向间接血凝试验检测囊虫循环抗原及其在疗效考核方面的应用  

Determination of the Circulating Antigen in Cysticercosis Patients by RIHA and Examination of Curative Effects by the Circulation Antigen

作　　者：张达琳 徐之杰 

出　　处：《哈尔滨医科大学学报》1996年第4期335-337,共3页Journal of Harbin Medical University

摘　　要：本文报告用铬离子单克隆抗体鞣酸法致敏绵羊红细胞作反向间接血凝试验，检测７７例囊虫病人血清循环抗原阳性率为６４９４％；６４例正常人血清的假阳性率为１５６％；２２例肝吸虫病人、２４例包虫病人和１７例弓形虫病人的交叉反应率分别为４５５％、４１７％和１１７６％。表明该法较为敏感、特异，且操作简单。但发现随着疗程增加，循环抗原的阴性率明显高于抗体的阴性率，且大部分病人循环抗原的消失与临床症状、体征的消失相一致。表明在囊虫病的诊断和疗效考核方面，检测循环抗原有一定的实用价值。The paper reported that the circulating antigen in cysticercosis patients' sera was detected by RIHA in the sheep's RBC which were sensitized by Cr 3+ ,McAb and tannin.The positive rate in 77 patients with cysticercosis was 64.94%,and in 64 healthy persons the false positive rate was 1.56%.In 24 echinococcosis patients,22 clonorchiosis ones and toxoplasmosis ones the positive rates were 4.17%,4.55% and 11.76%,respectively.The results showed that this method was sensitive,specificite and easy,especialy can be used in basic medical unit.The circulating antigen and antibody were detected in the sera from the cysticercosis patients of 1～10 courses.With increase of the courses the negative rates of the circulating antigen were clearly higher than the ones of the antibody,and with disappearance of the circulating antigen,the symptoms and signs of most patients disappeared,too.The results showed that detecting the circulating antigen has some applicable value in the diagnosis and examination of curative effect of the cysticercosis patients.

关 键 词：猪囊尾蚴 囊尾蚴病 循环抗原 间接血凝试验 

分 类 号：R532.330.4[医药卫生—内科学]