先天性痛觉迟钝和无汗症患者的眼部表现  

Ocular manifestations of congenital insensitivity to pain with anhidrosis

作　　者：Amano S. Fukuoka S. Usui T. 杨秀梅(译) 

机构地区：[1]不详 [2]7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan

出　　处：《世界核心医学期刊文摘（眼科学分册）》2006年第6期6-7,共2页Digest of the World Core Medical Journals:Ophthalmology

摘　　要：PURPOSE: To describe ocular manifestations in Japanese patients with congenital insensitivity to pain with anhidrosis (CIPA),focusing particularly on the status of the ocular surface. DESIGN: Observational case series. METHODS: Eighteen patients with CIPA underwent applicable ophthalmologic examinations,including visual acuity,refraction,slit-lamp examination,fundus examination,tear breakup time,Schirmer 1 test,corneal sensitivity,and corneal topography. RESULTS: Superficial punctate keratopathy (SPK) was observed at the interpalpebral area in 23 (64% ) of 36 eyes. Corneal opacity was observed in three eyes (8.3% ). Tear breakup time was below the lower limit of the normal range in all examined eyes,and the value of Schirmer 1 test was above the lower limit of the normal range in most of the examined eyes. CONCLUSIONS: Superficial punctate keratopathy is observed in most cases of CIPA,which might predispose patients to corneal infection. Investigation of dry eye in patients with CIPA will provide unique opportunities to explore the critical roles of the autonomic sympathetic nervous system as well as the sensory nervous system in the physiology of tear production.PURPOSE： To describe ocular manifestations in Japanese patients with congenital insensitivity to pain with anhidrosis （CIPA）, focusing particularly on the status of the ocular surface. DESIGN： Observational case series. METHODS： Eighteen patients with CIPA underwent applicable ophthalmologic examinations, including visual acuity, refraction, slit-lamp examination, fundus examination, tear breakup time, Schirmer 1 test, corneal sensitivity, and corneal topography. RESULTS： Superficial punctate keratopathy （SPK） was observed at the interpalpebral area in 23 （64%） of 36 eyes. Corneal opacity was observed in three eyes （8.3%）. Tear breakup time was below the lower limit of the normal range in all examined eyes, and the value of Schirmer 1 test was above the lower limit of the normal range in most of the examined eyes. CONCLUSIONS： Superficial punctate keratopathy is observed in most cases of CIPA, which might predispose patients to corneal infection. Investigation of dry eye in patients with CIPA will provide unique opportunities to explore the critical roles of the autonomic sympathetic nervous system as well as the sensory nervous system in the physiology of tear production.

关 键 词：眼部表现 痛觉迟钝 无汗症 先天性 患者 SCHIRMER 泪膜破裂时间 自主神经系统 眼科检查 CIPA 

分 类 号：R771.3[医药卫生—眼科] R573.1[医药卫生—临床医学]